MRSA Transmission Reduction Using Agent-Based Modeling and Simulation
MRSA Transmission Reduction Using Agent-Based Modeling and Simulation
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DOI：
10.1287/ijoc.1100.0386
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发表时间：
2010-09-01
影响因子：
2.1
通讯作者：
Wasil, Edward
中科院分区：
文献类型：
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作者：
Barnes, Sean;Golden, Bruce;Wasil, Edward
耐甲氧西林金黄色葡萄球菌 (MRSA) 是医疗保健领域一个持续存在的重大问题，也对医院和社区构成重大威胁。它在患者中的传播会造成许多下游影响，例如患者住院时间更长、医院和保险公司的成本更高以及死亡人数增加。开发了基于代理的模拟模型来研究医院内 MRSA 传播的动态。该模拟模型用于检查各种感染控制程序的有效性，并探索与医院管理人员和政策制定者相关的更具体的问题。进行模拟实验以检查手卫生依从性和功效、患者筛查、去殖民化、患者隔离以及医护人员与患者的比例对 MRSA 传播发生率和其他相关指标的影响。进行实验是为了调查直接归因于护士和医生（包括卫生条件差的流氓卫生保健工作者）的定植数量之间的动态关系。我们开始探索在实行高度手部卫生合规性和额外预防措施的医院中引发疫情爆发的最有可能的威胁。
Methicillin-resistant Staphylococcus aureus (MRSA) is a significant ongoing problem in health care, posing a substantial threat to hospitals and communities as well. Its spread among patients causes many downstream effects, such as a longer length of stay for patients, higher costs for hospitals and insurance companies, and fatalities. An agent-based simulation model is developed to investigate the dynamics of MRSA transmission within a hospital. The simulation model is used to examine the effectiveness of various infection control procedures and explore more specific questions relevant to hospital administrators and policy makers. Simulation experiments are performed to examine the effects of hand-hygiene compliance and efficacy, patient screening, decolonization, patient isolation, and health-care worker-to-patient ratios on the incidence of MRSA-transmission and other relevant metrics. Experiments are conducted to investigate the dynamic between the number of colonizations directly attributable to nurses and physicians, including rogue health-care workers who practice poor hygiene. We begin to explore the most likely threats to trigger an outbreak in hospitals that practice high hand-hygiene compliance and additional preventive measures.