Epidemiology of angle-closure glaucoma -: Prevalence, clinical types, and association with peripheral anterior chamber depth in the Egna-Neumarkt glaucoma study
Epidemiology of angle-closure glaucoma -: Prevalence, clinical types, and association with peripheral anterior chamber depth in the Egna-Neumarkt glaucoma study
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DOI：
10.1016/s0161-6420(00)00022-1
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发表时间：
2000-05-01
期刊：
影响因子：
13.7
通讯作者：
Varotto, A
中科院分区：
文献类型：
--
作者：
Bonomi, L;Marchini, G;Varotto, A
目的评估北方意大利特定人群中原发性闭角型青光眼（PACG）的患病率、不同临床表现的频率及其与周边前房深度的相关性。设计：特定人群的横断面流行病学研究。参与者：居住在南蒂罗尔州Egna-Neumarkt地区的所有受试者（北方意大利）和40岁以上的人被邀请接受眼科检查。干预措施筛选检查后，疑似青光眼的受试者在筛选中心重新检查以确认诊断。所有在第二次检查后仍被证明可疑的病例都进行了第三阶段的调查，并被归类为健康或明确昏迷。根据标准方案对每个受试者进行检查，包括病史询问、眼球后退和视力测定、眼部生物显微镜检查、通过货车Herick方法评价周边前房深度、压平眼压测量、视盘评价和计算机视野检查。在初始筛选期间未进行前房角镜检查，而仅在第二和第三研究阶段的所有选定患者中进行。PACG的诊断基于以下标准中至少两个的同时存在：眼内压大于或等于22 mmHg、青光眼性视盘异常、青光眼性视野缺损。此外，生物显微镜或前房角镜检查证实房角关闭也是必要的。周边前房深度的百分比分布、闭角型青光眼的患病率和不同PACG临床表现的频率。结果：检查了4297名受试者（总体参与率为73.9%）。根据货车Herick方法，14.7%的人群的前房周边深度为2级，2.5%为1级，0.3%为0级。闭角型青光眼的总患病率为0.6%（26例）。其中5例是以前的急性发作解决的治疗，慢性房角关闭急性发作后的情况下，三个是间歇性房角关闭性青光眼，和15个慢性房角关闭cases.Conclusions：闭塞的角度更频繁比其他白色人口以前研究。PACG的患病率并不像通常认为的那样低;这种类型的青光眼占Egna-Neumarkt人群中发现的所有青光眼的四分之一以上。最常见的临床表现是慢性闭角型青光眼。(C)2000年由美国眼科学会。
Objectives To assess the prevalence of primary angle-closure glaucoma (PACG), the frequency of its different clinical presentations, and its association with peripheral anterior chamber depth in a defined population in Northern Italy.Design: Cross-sectional epidemiologic study in a defined population.Participants: All subjects resident in the Egna-Neumarkt area of the South Tyrol Region (Northern Italy) and more than 40 years of age were invited to undergo an ophthalmologic examination.Interventions After the screening examination, subjects with suspected glaucoma were re-examined at the screening center to confirm the diagnosis. All cases that still proved suspect after the second examination underwent a third phase of investigations and were classified as healthy or as definitely glaucomatous. Each subject was examined according to a standard protocol, including medical history interview, retraction and visual acuity determination, ocular biomicroscopy, evaluation of peripheral anterior chamber depth by means of the Van Herick method, applanation tonometry, optic disc evaluation, and computerized perimetry. Gonioscopy was not performed during initial screening but only in all selected patients in the second and third phases of investigations. The diagnosis of PACG was made on the basis of the concomitant presence of at least two of the following criteria: intraocular pressure greater than or equal to 22 mmHg, glaucomatous optic disc abnormalities, glaucomatous visual field defects. In addition, biomicroscopic or gonioscopic evidence of angle closure was also necessary.Main Outcome Measures.' Percentage distribution of peripheral anterior chamber depths, prevalence of angle-closure glaucoma, and frequency of the different PACG clinical presentations.Results: Four thousand two hundred ninety-seven subjects were examined (73.9% overall participation rate). The peripheral depth of the anterior chamber according to the Van Herick method was grade 2 in 14.7%, grade 1 in 2.5%, and grade 0 in 0.3% of the population. The overall prevalence of angle-closure glaucoma was 0.6% (26 cases). Five of these were cases of previous acute attacks resolved by therapy, three were cases of chronic angle-closure after acute attacks, three were intermittent angle-closure glaucomas, and 15 were chronic angle-closure cases.Conclusions: Occludable angles were more frequent than in other white populations previously studied. The prevalence of PACG is not as low as is usually believed; this type of glaucoma accounts for more than a quarter of all glaucomas found in the Egna-Neumarkt population. The most frequent clinical presentation is chronic angle-closure glaucoma. (C) 2000 by the American Academy of Ophthalmology.