The structural and functional development of the retina in larval Xenopus.
The structural and functional development of the retina in larval Xenopus.
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非洲爪蟾幼虫视网膜的结构和功能发育。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
Gaze
中科院分区：
文献类型：
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作者：
H. S;Chung;R.;V. Stirling;M. R;Gaze
利用组织学和电生理学技术研究了非洲爪蟾幼虫视网膜在连续发育阶段的结构转变以及视网膜神经节细胞反应特征的随之变化。视觉诱发电反应的第一个迹象大约出现在神经节细胞展开成单层时，以及内丛状层和外丛状层变得可辨别后不久。最初给出简单的“开启”响应，细胞逐渐改变其响应特征并成为“事件”单元。随后，可以识别“调光”单元。在幼虫的整个生命周期中，这两种类型的反应特性变得更加明显，并且与成虫的反应特性更加接近。神经节细胞树突树的树枝化模式也是如此。在高尔基体制备物中可以识别两种类型的分支模式。在变态高潮前后，出现了一种新型神经节细胞，与电生理学上“持续”单位的出现同时发生。变态后，视网膜的厚度（主要在内丛状层）和直径仍然增长。这三种单元类型发生变化，使得它们在感受野上表现出来自周边视野的明显抑制作用，并且每种单元类型获得独特的内源性放电模式。
The structural transformations of the larval Xenopus retina at successive stages of development, and concomitant changes in response characteristics of retinal ganglion cells, were studied using histological and electrophysiological techniques. The first sign of visually evoked electrical responses appears at about the time when the ganglion cells spread out into a single layer and shortly after the inner and outer plexiform layers become discernible. Initially giving simple "on" responses, the cells progressively change their response characteristics and become "event" units. Subsequently, "dimming" units can be identified. Throughout larval life, response properties of these two types become more distinct from one another and approximate to those found in the adult. So do the arborization patterns of the dendritic trees of the ganglion cells. Two types of branching patterns are identifiable in Golgi preparations. Around metamorphic climax, a new type of ganglion cell appears, coinciding with the emergence of "sustained" units electrophysiologically. After metamorphosis, the retina still grows both in thickness (mainly in the inner plexiform layer) and diameter. The three unit types change such they they come to show pronounced inhibitory effects from the peripheral visual field on the receptive field and each unit type acquires a distinct pattern of endogenous discharge.