Influence of Personality on the Relationship Between Gray Matter Volume and Neuropsychiatric Symptoms in Multiple Sclerosis
Influence of Personality on the Relationship Between Gray Matter Volume and Neuropsychiatric Symptoms in Multiple Sclerosis
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DOI：
10.1097/psy.0b013e31828837cc
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发表时间：
2013-04-01
影响因子：
3.3
通讯作者：
Zivadinov, Robert
中科院分区：
文献类型：
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作者：
Benedict, Ralph H. B.;Schwartz, Carolyn E.;Zivadinov, Robert
目的：研究揭示了人格特质和健康结果之间的关联，在多发性硬化症（MS）中，有初步数据显示人格特质和脑容量之间的相关性。我们研究了人格影响灰质体积（GMV）和认知/神经精神MS功能之间的关系的一般假设。研究方法：参与者是98名MS患者，他们接受了磁共振成像，并接受了符号数字模式测试和神经精神量表的测试，后者提供了MS的特征，即愉快的冷漠和去抑制的抑郁和欣快的测量。人格特质采用NEO五因素量表进行评估。我们研究了人格特质与GMV和症状之间的相关性，然后对GMV与认知/神经精神特征之间的关系进行了中介和适度影响。结果如下：线性回归模型显示，GMV（r = 0.54，p <0.001）和NEO五因素量表低敏感度（r = 0.36，p = 0.001）与认知功能相关，但未观察到中介或调节效应。然而，兴奋性介导了GMV和欣快症状之间的关系（p = .002）。调节分析显示，高神经质对GMV-欣快关系有显著影响（p = 0.029）。结论：低兴奋性和高神经质与MS的神经精神并发症相关，并且各自影响GMV和欣快之间的关系。研究结果表明，低焦虑的患者患MS相关认知功能障碍和神经精神症状的风险较高，这一结论对人格在临床神经科学中的新兴作用具有影响。
Objective: Research has revealed an association between personality traits and health outcomes, and in multiple sclerosis (MS), there are preliminary data showing a correlation between personality traits and brain volume. We examined the general hypothesis that personality influences the relationship between gray matter volume (GMV) and cognitive/neuropsychiatric MS features. Methods: Participants were 98 patients with MS who underwent magnetic resonance imaging and were tested with the Symbol Digit Modalities Test and the Neuropsychiatric Inventory, the latter providing measures of depression and euphoria that can be characteristic of MS, that is, cheerful indifference and disinhibition. Personality traits were assessed with the NEO Five Factor Inventory. We examined the correlation between personality traits and both GMV and symptoms, and then modeled mediation and moderation influences on the relationships between GMV and cognitive/neuropsychiatric features. Results: Linear regression modeling revealed that GMV (r = 0.54, p < .001) and NEO Five Factor Inventory low conscientiousness (r = 0.36, p = .001) were associated with cognitive function, but no mediator or moderator effects were observed. However, conscientiousness mediated the relationship between GMV and symptoms of euphoria (p = .002). The moderator analysis revealed a significant influence of high neuroticism on the GMV-euphoria relationship (p = .029). Conclusions: Low conscientiousness and high neuroticism are associated with neuropsychiatric complications in MS, and each influences the relationship between GMV and euphoria. The findings suggest that patients with low conscientiousness are at higher risk for MS-associated cognitive dysfunction and neuropsychiatric symptoms, a conclusion that has implications for the emerging role of personality in clinical neuroscience.