A preliminary study of functional brain activation among marijuana users during performance of a virtual water maze task.
A preliminary study of functional brain activation among marijuana users during performance of a virtual water maze task.
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大麻使用者在执行虚拟水迷宫任务期间大脑功能激活的初步研究。
DOI：
10.1155/2013/461029
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发表时间：
2013
影响因子：
--
通讯作者：
Yurgelun-Todd,DeborahA
中科院分区：
文献类型：
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作者：
Sneider,JenniferTropp;Gruber,StaciA;Rogowska,Jadwiga;Silveri,MarisaM;Yurgelun-Todd,DeborahA
许多研究报告了与长期使用大麻有关的神经认知障碍。鉴于海马体含有高密度的大麻素受体，海马体介导的认知功能，包括视觉空间记忆，可能会增加对慢性大麻使用的脆弱性。因此，目前的研究检查大脑激活过程中的一个虚拟的模拟经典的莫里斯水迷宫任务在10个慢性大麻（MJ）用户相比，18个nonusing（NU）比较科目。在回收（隐藏平台）和运动控制（可见平台）条件下，使用血氧水平依赖性（BOLD）功能MRI在3.0 T下采集成像数据。虽然学习试验的任务表现是相似的组之间，MJ用户表现出记忆检索的赤字。对于BOLD fMRI数据，NU受试者在右侧海马旁回和扣带回中表现出比MJ组更大的激活，用于检索-运动控制对比（NU > MJ）。这些研究结果表明，MJ用户的低激活可能是由于在检索记忆的神经资源的有效利用的差异。鉴于有关MJ使用者视觉空间记忆功能的数据很少，这些发现可能有助于阐明大麻在记忆检索期间对大脑激活的神经生物学影响。
Numerous studies have reported neurocognitive impairments associated with chronic marijuana use. Given that the hippocampus contains a high density of cannabinoid receptors, hippocampal‐mediated cognitive functions, including visuospatial memory, may have increased vulnerability to chronic marijuana use. Thus, the current study examined brain activation during the performance of a virtual analogue of the classic Morris water maze task in 10 chronic marijuana (MJ) users compared to 18 nonusing (NU) comparison subjects. Imaging data were acquired using blood oxygen level‐dependent (BOLD) functional MRI at 3.0 Tesla during retrieval (hidden platform) and motor control (visible platform) conditions. While task performance on learning trials was similar between groups, MJ users demonstrated a deficit in memory retrieval. For BOLD fMRI data, NU subjects exhibited greater activation in the right parahippocampal gyrus and cingulate gyrus compared to the MJ group for the Retrieval‐Motor Control contrast (NU > MJ). These findings suggest that hypoactivation in MJ users may be due to differences in the efficient utilization of neuronal resources during the retrieval of memory. Given the paucity of data on visuospatial memory function in MJ users, these findings may help elucidate the neurobiological effects of marijuana on brain activation during memory retrieval.