Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.
Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.
复制标题
绘制大鼠 2 号染色体上血压数量性状位点的图谱。
DOI：
10.1172/jci117341
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
John P. Rapp
中科院分区：
文献类型：
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作者：
A. Deng;H. Dene;John P. Rapp
在含有血压数量性状位点（QTL）的区域构建了包含5个血压调节候选基因的大鼠2号染色体遗传图谱。研究了断奶后高盐（8%NaCl）饮食饲养的两个F2雄性大鼠群体：F2（WKY x S），来自Dahl盐敏感大鼠（S）和Wistar-Kyoto大鼠（WKY）的杂交; F2（MNS x S），来自S大鼠和米兰血压正常品系（MNS）的杂交。在这两个群体中，血压QTL位于Na+，K（+）-ATP酶α 1亚型和钙调蛋白依赖性蛋白激酶II-δ位点之间。基于组合群体（n = 330），该血压QTL存在的LOD值为5.66，解释总方差的9.2%，解释遗传方差的26%。
A genetic map for rat chromosome 2 that includes five candidate genes for blood pressure regulation was constructed in a region containing a quantitative trait locus (QTL) for blood pressure. Two F2 populations of male rats raised on high salt (8% NaCI) diet from weaning were studied: F2(WKY x S), derived from a cross of Dahl salt-sensitive rats (S) and Wistar-Kyoto rats (WKY); and F2(MNS x S), derived from a cross of S rats and Milan normotensive strain (MNS). In both populations a blood pressure QTL was localized between Na+,K(+)-ATPase alpha 1 isoform and calmodulin-dependent protein kinase II-delta loci. The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance.