Longitudinal changes in bone in men with spinal cord injury
Longitudinal changes in bone in men with spinal cord injury
复制标题
DOI：
10.1191/026921500670532165
复制
发表时间：
2000-04-01
影响因子：
3
通讯作者：
Stüssi, E
中科院分区：
文献类型：
--
作者：
de Bruin, ED;Dietz, V;Stüssi, E
前言：目前骨的定量评估主要基于骨密度(BMD)的分析。目的：应用外周定量CT和生物力学测试方法(骨刚性测试仪摆动)研究12例脊髓损伤患者胫骨纵向结构和几何特性的变化。设计：在某大学医院脊髓损伤后第5周和第104周左右进行测量。结果：配对t检验显示骨小梁(p<；0.05)和皮质骨(p<；在脊髓损伤后两年内，胫骨的几何性质显著下降(p<；0.05)。3名受试者在脊髓损伤后2年内相速度传播发生改变。结论：脊髓损伤后，除了组织成分、骨几何指标和结构特性的变化外，在胫骨中，结合骨的几何和生物力学参数结合骨密度测量，可以更好地筛查脊髓损伤相关的骨量减少和预测脊髓损伤的骨折风险。
Introduction: Quantitative bone assessment today is primarily based on the analysis of bone mineral density (BMD). The geometric and structural properties of bone, which are important parameters for skeletal strength, are generally not considered in the routine clinical assessment of spinal cord injury-related osteopenia.Objective: To study changes in structural and geometric properties of tibia bone longitudinally by means of peripheral quantitative computerized tomography and a biomechanical test method (bone stiffness measurement device Swing) in 12 subjects with spinal cord injury.Design: Measurements were conducted in the 5th week and around the 104th week after the spinal cord injury in a university hospital.Results: Paired Student's t-tests showed a significant decrease in trabecular (p < 0.05) and cortical bone (p < 0.05), as well as a significant decrease in geometric properties of tibia bone (p < 0.05) within two years after the spinal cord injury. Phase velocity propagation changed in three subjects within two years following the spinal cord injury.Conclusions: This study indicates that beside changes in tissue composition, changes in bone geometric indices and in structural properties occur in the lower extremity after a spinal cord injury, In the tibia, consideration of geometric and biomechanical parameters of bone combined with bone mineral density measurements could result in an improved screening for spinal cord injury-related osteopenia and the prediction of fracture risk in spinal cord injury.