Metabolic signatures associated with Western and Prudent dietary patterns in women
Metabolic signatures associated with Western and Prudent dietary patterns in women
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DOI：
10.1093/ajcn/nqaa131
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发表时间：
2020-08-01
影响因子：
7.1
通讯作者：
Rexrode, Kathryn M.
中科院分区：
文献类型：
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作者：
Chandler, Paulette D.;Balasubramanian, Raji;Rexrode, Kathryn M.
背景资料：西方饮食模式（WD）与冠状动脉疾病（CAD）和癌症的风险呈正相关，而谨慎饮食模式（PD）可能具有保护作用。食物可能会影响代谢物浓度以及氧化应激和脂质失调，与CAD和cancer.Objective相关的生物学机制：目的是评估2种衍生的饮食模式评分与血清代谢物的相关性，并确定与代谢物相关的代谢途径。方法：我们评估了2199名妇女健康倡议（WHI）参与者的每种饮食模式（WD，PD）和代谢物之间的横截面关联。通过因子分析和FFQ，我们确定了两种符合WD和PD的膳食模式。代谢物测定与LC-串联MS。代谢物的发现904 WHI观察性研究（WHI-OS）的参与者中复制1295 WHI激素治疗试验（WHI-HT）的参与者。我们分析了每495代谢物与每个膳食评分（WD，PD）在线性回归models.Results：PD包括较高的蔬菜和水果摄入量相比，WD与较高的饱和脂肪和肉类摄入量。独立于能量摄入、BMI、体力活动和其他混杂变量，鉴定了45种重叠代谢物（WHI-OS）并重复了45种重叠代谢物（WHI-HT），其中WD与PD的关联方向相反[错误发现率（FDR）P <0.05]。在代谢物组富集分析中，磷脂酰乙醇胺（PE）缩醛磷脂与WD呈正相关[标准化富集评分（内斯）= 2.01，P = 0.001，FDR P = 0.005]，胆固醇酯与WD呈正相关[标准化富集评分（NES）= 2.01，P = 0.001，FDR P = 0.005]。（内斯=-1.77，P = 0.005，FDR P = 0.02）和磷脂酰胆碱（内斯=-1.72，P = 0.01，P = 0.03）对WD呈负富集。PE缩醛磷脂与饱和脂肪和红肉呈正相关。磷脂酰胆碱和胆固醇酯与脂肪fish.Conclusions：与西方和谨慎的饮食模式相关的独特的代谢物签名突出了线粒体氧化应激和脂质失调与WD的正相关和与PD的负相关。
Background: The Western dietary pattern (WD) is positively associated with risk of coronary artery disease (CAD) and cancer, whereas the Prudent dietary pattern (PD) may be protective. Foods may influence metabolite concentrations as well as oxidative stress and lipid dysregulation, biological mechanisms associated with CAD and cancer.Objective: The aim was to assess the association of 2 derived dietary pattern scores with serum metabolites and identify metabolic pathways associated with the metabolites.Methods: We evaluated the cross-sectional association between each dietary pattern (WD, PD) and metabolites in 2199 Women's Health Initiative (WHI) participants. With FFQ and factor analysis, we determined 2 dietary patterns consistent with WD and PD. Metabolites were measured with LC-tandem MS. Metabolite discovery among 904 WHI Observational Study (WHI-OS) participants was replicated among 1295 WHI Hormone Therapy Trial (WHI-HT) participants. We analyzed each of 495 metabolites with each dietary score (WD, PD) in linear regression models.Results: The PD included higher vegetables and fruit intake compared with the WD with higher saturated fat and meat intake. Independent of energy intake, BMI, physical activity, and other confounding variables, 45 overlapping metabolites were identified (WHI-OS) and replicated (WHI-HT) with an opposite direction of associations for the WD compared with the PD [false discovery rate (FDR) P < 0.05]. In metabolite set enrichment analyses, phosphatidylethanolamine (PE) plasmalogens were positively enriched for association with WD [normalized enrichment score (NES) = 2.01, P = 0.001, FDR P = 0.005], and cholesteryl esters (NES=-1.77, P = 0.005, FDR P = 0.02), and phosphatidylcholines (NES = -1.72, P = 0.01, P = 0.03) were negatively enriched for WD. PE plasmalogens were positively correlated with saturated fat and red meat. Phosphatidylcholines and cholesteryl esters were positively correlated with fatty fish.Conclusions: Distinct metabolite signatures associated with Western and Prudent dietary patterns highlight the positive association of mitochondrial oxidative stress and lipid dysregulation with a WD and the inverse association with a PD.