Effects of Sasa Health, extract of bamboo grass leaves, on spontaneous mammary tumourigenesis in SHN mice.
Effects of Sasa Health, extract of bamboo grass leaves, on spontaneous mammary tumourigenesis in SHN mice.
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DOI：
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发表时间：
1998
影响因子：
2
通讯作者：
S. Tsunoda;K. Yamamoto;S. Sakamoto;H. Inoue;H. Nagasawa
中科院分区：
文献类型：
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作者：
S. Tsunoda;K. Yamamoto;S. Sakamoto;H. Inoue;H. Nagasawa
在饮用水中以0.044%-0.088%Fe-叶绿酸钠的浓度用碱水解获得的竹草叶提取物Sasa Health进行慢性治疗，导致SHN处女小鼠的高乳腺肿瘤品系中自发性乳腺肿瘤的发育和生长的显著抑制。对具有明显大小的乳腺肿瘤的小鼠进行12天的有限治疗也明显延缓了肿瘤的生长。结果表明，该药物能促进正常乳腺的终末芽形成和胸苷酸合成酶活性，但抑制癌前乳腺增生性肺泡结节的形成。长期摄入莎莎健康刺激尿液成分的排泄，降低和增加血清中的催乳素水平和超氧化物歧化酶活性，分别。它对食物和水的摄入量，身体生长和任何外观都没有有害影响，所有研究结果表明，Sasa Health可能是一种有前途的保护和治疗乳腺癌和其他类型肿瘤的药物。
Chronic treatment with Sasa Health, extract of bamboo grass leaves obtained by alkaline hydrolysis, in drinking water at the concentration of 0.044%-0.088% Fe-Chlorophyllin Na resulted in the significant inhibition of both development and growth of spontaneous mammary tumours in a high mammary tumour strain of SHN virgin mice. Limited treatment for 12 days in mice with palpable sizes of mammary tumours also markedly retarded the growth of the tumours. The end-bud formation and thymidylate synthetase activity of normal mammary glands were stimulated, but the formation of preneoplastic mammary hyperplastic alveolar nodules was inhibited by the treatment. Chronic ingestion of Sasa Health stimulated the excretion of urine components and decreased and increased the prolactin level and superoxide dismutase activity in serum, respectively. It showed no deleterious effects on food and water intake, body growth and any external appearance and all findings indicate that Sasa Health could be a promising agent for the protection and therapy of breast and other types of tumours.