Multifunctional 3D-Printed Patches for Long-Term Drug Release Therapies after Myocardial Infarction
Multifunctional 3D-Printed Patches for Long-Term Drug Release Therapies after Myocardial Infarction
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DOI：
10.1002/adfm.202003440
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发表时间：
2020-07-01
影响因子：
19
通讯作者：
Rojas, Orlando J.
中科院分区：
文献类型：
--
作者：
Ajdary, Rubina;Ezazi, Nazanin Zanjanizadeh;Rojas, Orlando J.
一种生物材料系统纳入纳米纤维素，聚（甘油癸酸酯），聚吡咯是介绍治疗心肌梗死。多组分水悬浮液的直接墨水书写允许多功能晶格结构，不仅具有弹性和导电性，而且能够促进细胞生长。考虑到它们与H9c2成心肌细胞的生物相容性，它们在微观结构水平上广泛附着，并诱导其增殖28天，因此被认为是心脏贴片。两种模型药物（3i-1000和姜黄素）被研究了它们在斑块中的整合，要么通过装载在用于挤压的前体悬浮液中，要么通过直接浸渍获得的干燥晶格。在为期5个月的药物释放研究中，观察到心脏贴片的体外缓慢降解，这可以防止药物爆裂释放，并表明它们适合长期治疗。生物相容性、生物可降解性、机械强度、柔韧性和导电性的结合满足了高动态和功能性电反应心脏组织的要求。总的来说，提出的心脏贴片是通过心肌细胞与生物材料的有效整合来实现梗死后心肌再生的可行替代方案。
A biomaterial system incorporating nanocellulose, poly(glycerol sebacate), and polypyrrole is introduced for the treatment of myocardial infarction. Direct ink writing of the multicomponent aqueous suspensions allows multifunctional lattice structures that not only feature elasticity and electrical conductivity but enable cell growth. They are proposed as cardiac patches given their biocompatibility with H9c2 cardiomyoblasts, which attach extensively at the microstructural level, and induce their proliferation for 28 days. Two model drugs (3i-1000 and curcumin) are investigated for their integration in the patches, either by loading in the precursor suspension used for extrusion or by direct impregnation of the as-obtained, dry lattice. In studies of drug release conducted for five months, a slow in vitro degradation of the cardiac patches is observed, which prevents drug burst release and indicates their suitability for long-term therapy. The combination of biocompatibility, biodegradability, mechanical strength, flexibility, and electrical conductivity fulfills the requirement of the highly dynamic and functional electroresponsive cardiac tissue. Overall, the proposed cardiac patches are viable alternatives for the regeneration of myocardium after infarction through the effective integration of cardiac cells with the biomaterial.