Urinary 6β‐hydroxycortisol excretion in Hong Kong Chinese patients with hepatocellular carcinoma and other chronic liver diseases
Urinary 6β‐hydroxycortisol excretion in Hong Kong Chinese patients with hepatocellular carcinoma and other chronic liver diseases
复制标题
香港华人肝细胞癌及其他慢性肝病患者尿 6β-羟基皮质醇排泄
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
A. Li
中科院分区：
文献类型：
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作者：
M. Ng;R. P. Young;J. Critchley;N. Leung;J. Lau;A. Li
细胞色素P-450通过细胞色素P-450将外源物质生物转化为有毒的代谢物，与肿瘤的发生有关。本研究通过测定肝细胞癌和其他慢性肝病患者尿液中6-羟基皮质醇(6-β-羟皮质醇，6-β)与游离皮质醇(F)的比值，研究了代谢激活黄曲霉毒素B1等前致癌物的细胞色素P3A4活性。
The biotransformation of xenobiotics into toxic metabolites by cytochrome P‐450 has been implicated in carcinogenesis. This study investigated CYP3A4 activity, which metabolically activates procarcinogens such as aflatoxin B1, by measuring the urinary 6β‐hydroxycortisol (6βOHF) to free cortisol (F) ratio in patients with hepatocellular carcinoma (HCC) and other chronic liver diseases.
通过高效液相色谱法测量尿液 6 β-羟基皮质醇/皮质醇比率，用作人细胞色素 P-450 3A4 的生物标志物。
DOI：
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发表时间：
1992
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
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作者：
Joellenbeck,L;Qian,Z;Zarba,A;Groopman,JD
通讯作者：
Groopman,JD