The Dimension of Titania Nanotubes Influences Implant Success for Osteoclastogenesis and Osteogenesis Patients
The Dimension of Titania Nanotubes Influences Implant Success for Osteoclastogenesis and Osteogenesis Patients
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DOI：
10.1166/jnn.2015.9602
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发表时间：
2015-06-01
影响因子：
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通讯作者：
Xiong, Wei
中科院分区：
文献类型：
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作者：
Li, Yong;Li, Feng;Xiong, Wei
能够抑制破骨细胞生成并增强骨生成的植入物是骨质疏松症患者所期望的。在这项研究中，分别通过10、40和60 V的阳极氧化分别生产了纳米管直径为30、80和120 nm的二氧化钛纳米管(Ti-NT)材料。将 Ti-NT 引入钛基材显着减少了样品上破骨细胞的形成和活性。随着纳米管直径的增大，破骨细胞数量、抗酒石酸酸性磷酸酶染色和活性以及破骨细胞相关基因表达进一步降低。通过增加纳米管直径来增强成骨能力。因此，较大直径的纳米管植入物，如NT60，能够更好地抑制骨吸收并增强骨形成，以防止植入物丢失和失败，特别是对于骨质疏松症患者。
Implants that can inhibit osteoclastogenesis and enhance osteogenesis are desirable for osteoporosis patients. In this study, titania nanotube (Ti-NT) materials, having nanotube diameters of 30, 80, and 120 nm, were produced separately by anodization at 10, 40, and 60 V, respectively. The introduction of Ti-NTs to titanium substrates significantly reduced the formation and activity of osteoclasts on samples. With the enlargement of the nanotube diameter, the osteoclasts number, tartrate-resistant acid phosphatase staining and activity, and related gene expressions of osteoclasts were further reduced. Osteogenic ability was enhanced by increasing the nanotube diameter. Thus, larger-diameter nanotube implants, such as NT60, were better able to inhibit bone absorption and enhance bone formation to prevent implant loss and failure, especially for osteoporosis patients.