Oxidative stress and antibody levels to periodontal bacteria in adults: the Nagasaki Islands study.
Oxidative stress and antibody levels to periodontal bacteria in adults: the Nagasaki Islands study.
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DOI：
10.1111/odi.12127
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发表时间：
2014-04
期刊：
影响因子：
3.8
通讯作者：
N. Tamaki;H. Hayashida;M. Fukui;M. Kitamura;K. Kawasaki;M. Nakazato;T. Maeda;Toshiyuki Saito;Hiro-o Ito
中科院分区：
文献类型：
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作者：
N. Tamaki;H. Hayashida;M. Fukui;M. Kitamura;K. Kawasaki;M. Nakazato;T. Maeda;Toshiyuki Saito;Hiro-o Ito
目的牙周炎是一种由龈下菌斑引起的支持牙齿组织的慢性炎症性疾病。全身活性氧的增加与牙周炎的发病机制有关。本研究在一项基于社区的研究中探讨了血清氧化应激水平和抗假定牙周病细菌抗体之间的关系及其与牙周状况的关系。研究对象和方法测定血清样品的活性氧代谢产物（ROM）水平和抗氧化能力。ELISA法检测血清牙龈卟啉单胞菌（Pg）、中间普雷沃氏菌（Pi）、放线菌聚集菌（Aa）、腐蚀艾肯氏菌（Ec）免疫球蛋白G （IgG）抗体水平。结果临床依附丧失越严重的受试者血清ROM水平和Pg IgG抗体滴度越高，血清ROM水平与Pg、Pi和Ec抗体滴度呈正相关。在多变量logistic分析中，将探诊袋深度和临床依恋缺失作为因变量时，高ROM水平显示出具有统计学意义的相关性；校正后的优势比分别为2.9（95%可信区间= 1.0 ~ 8.5）和6.0（95%可信区间= 2.0 ~ 17.6）。结论：氧化应激增加可能对日本社区居民的牙周炎有害。
OBJECTIVE Periodontitis is a chronic inflammatory disease of the tissues supporting the teeth and is caused by subgingival plaque. Systemic increases in reactive oxygen species are involved in pathogenesis of periodontitis. This study addressed the relationship between levels of serum oxidative stress and antibodies against putative periodontopathic bacteria and their association with periodontal conditions, in a community-based study. SUBJECTS AND METHODS Serum samples were measured for reactive oxygen metabolite (ROM) levels and anti-oxidant capacity. The serum levels of immunoglobulin G (IgG) antibodies to Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Aggregatibacter actinomycetemcomitans (Aa), and Eikenella corrodens (Ec) were determined by ELISA. RESULTS The participants with greater clinical attachment loss had higher serum ROM levels and IgG antibody titers to Pg. Serum ROM levels were positively correlated with antibody titers to Pg, Pi, and Ec. When the participants with greater probing pocket depth and clinical attachment loss were used as the dependent variables, high ROM levels showed a statistically significant associations in multivariate logistic analyses; the adjusted odds ratios were 2.9 (95% confidence interval = 1.0-8.5) and 6.0 (95% confidence interval = 2.0-17.6), respectively. CONCLUSIONS It was concluded that an increased oxidative stress may be detrimental to periodontitis in Japanese community-dwelling adults.