Microfluidics at Fiber Tip for Nanoliter Delivery and Sampling.
Microfluidics at Fiber Tip for Nanoliter Delivery and Sampling.
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DOI：
10.1002/advs.202004643
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Yang GZ
中科院分区：
文献类型：
--
作者：
Barbot A;Wales D;Yeatman E;Yang GZ
输送和采样纳升体积的液体可以使新的侵入性外科手术受益。然而，死体积和产生恒压流动的困难限制了毛细管等小管子的使用。这项工作展示了直接组装在两束疏水涂层100微米毛细管尖端的亚毫米微流控芯片，以在液体环境中提供纳升液滴。液滴在专门设计的纳米管中产生，并由气体通过毛细管推进到微流控芯片，在微流控芯片中，被动阀门机构将液体与气体分离，使其得以输送。通过调整驱动压力和微流控几何形状，演示了部分和全部交付10纳升液滴的最大误差为0.4纳升，以及从环境中采样。该系统将使用微创探头进行药物输送和采样，促进用于疾病监测和体内药物筛选的连续液体活检。提出了一种安装在毛细管束上的微流控装置，用于精确的纳升液滴输送和采样。采用双光子聚合技术制作了亚毫米级的微流控芯片，并将其安装在双毛细管组件上。该芯片有许多被动阀，只让液体流向外部。这允许对液滴进行纳升的精确输送和采样。
Delivery and sampling nanoliter volumes of liquid can benefit new invasive surgical procedures. However, the dead volume and difficulty in generating constant pressure flow limits the use of small tubes such as capillaries. This work demonstrates sub‐millimeter microfluidic chips assembled directly on the tip of a bundle of two hydrophobic coated 100 µm capillaries to deliver nanoliter droplets in liquid environments. Droplets are created in a specially designed nanopipette and propelled by gas through the capillary to the microfluidic chip where a passive valve mechanism separates liquid from gas, allowing their delivery. By adjusting the driving pressure and microfluidic geometry, both partial and full delivery of 10 nanoliter droplets with 0.4 nanoliter maximum error, as well as sampling from the environment are demonstrated. This system will enable drug delivery and sampling with minimally invasive probes, facilitating continuous liquid biopsy for disease monitoring and in vivo drug screening. A microfluidic mount on capillaries bundle for precise nanolitre droplet delivery and sampling is presented. A sub‐millimetric microfluidic chip made by two‐photon polymerization is mounted on a dual capillary assembly. The chip has many passive valves to let only liquid flow to the outside. This allows nanoliter precision delivery and sampling of liquid droplets.
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影响因子：
2.7
作者：
Cho, SK;Moon, HJ;Kim, CJ
通讯作者：
Kim, CJ
影响因子：
4.6
作者：
Latka, Andrzej;Boelens, Arnout M. P.;de Pablo, Juan J.
通讯作者：
de Pablo, Juan J.
DOI：
10.1016/0166-6622(90)80068-f
发表时间：
1990-07-01
期刊：
COLLOIDS AND SURFACES
影响因子：
--
作者：
BLAKE, TD
通讯作者：
BLAKE, TD
影响因子：
35
作者：
Gissibl, Timo;Thiele, Simon;Giessen, Harald
通讯作者：
Giessen, Harald
影响因子：
13.3
作者：
Power, Maura;Thompson, Alex J.;Yang, Guang-Zhong
通讯作者：
Yang, Guang-Zhong