The Mediating Roles of Neurobiomarkers in the Relationship Between Education and Late-Life Cognition.
The Mediating Roles of Neurobiomarkers in the Relationship Between Education and Late-Life Cognition.
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DOI：
10.3233/jad-230244
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发表时间：
2023
影响因子：
4
通讯作者：
Eng, Chloe W.
中科院分区：
文献类型：
--
作者：
Amofa-Ho, Priscilla A.;Stickel, Ariana M.;Chen, Ruijia;Kobayashi, Lindsay C.;Glymour, M. Maria;Eng, Chloe W.
关键词：
神经病理学和神经血管损伤在早期生活教育和晚年认知功能之间的关系中的中介作用尚不清楚。检查阿尔茨海默氏症和神经血管生物标记物是否在教育和认知功能之间的关系中起中介作用。数据来自阿尔茨海默病神经成像计划3的537名年龄在55-94岁的成年人。我们测试了教育(连续、年限)和认知功能(记忆、执行功能和语言组合)之间的关系是否由神经成像生物标记物(海马体体积、皮质灰质体积、亚颞叶tau PET标准摄取值比率和白质高强度体积)中介。模型根据年龄、种族、性别/性别、心血管病史、体重指数、抑郁症和载脂蛋白E-ɛ4状态进行了调整。海马体体积和白质高信号在所有领域的教育和认知功能之间的关系中起部分中介作用(6.43%到15.72%中介)。教育对每个认知领域的直接影响都很强，且具有统计学意义。通常测量的神经生物标记物只能部分调节教育和多领域认知功能之间的关系。
The mediating roles of neuropathologies and neurovascular damage in the relationship between early-life education and later-life cognitive function are unknown. To examine whether Alzheimer’s and neurovascular biomarkers mediate the relationships between education and cognitive functions. Data were from 537 adults aged 55–94 in the Alzheimer’s Disease Neuroimaging Initiative 3. We tested whether the relationships between education (continuous, years) and cognitive function (memory, executive functioning, and language composites) were mediated by neuroimaging biomarkers (hippocampal volumes, cortical gray matter volumes, meta-temporal tau PET standard uptake value ratio, and white matter hyperintensity volumes). Models were adjusted for age, race, sex/gender, cardiovascular history, body mass index, depression, and Apolipoprotein E-ɛ4 status. Hippocampal volumes and white matter hyperintensities partially mediated the relationships between education and cognitive function across all domains (6.43% to 15.72% mediated). The direct effects of education on each cognitive domain were strong and statistically significant. Commonly measured neurobiomarkers only partially mediate the relationships between education and multi-domain cognitive function.