Simultaneous motor preparation and execution in a last-moment reach correction task
Simultaneous motor preparation and execution in a last-moment reach correction task
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DOI：
10.1038/s41467-019-10772-2
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发表时间：
2019-06-20
影响因子：
16.6
通讯作者：
Shenoy, Krishna, V
中科院分区：
文献类型：
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作者：
Ames, K. Cora;Ryu, Stephen, I;Shenoy, Krishna, V
运动准备通常先于运动，并被认为决定即将到来的运动的性质。然而，准备的研究大多是在点对点延迟到达任务中进行的。在这里，我们询问在中游改造期间是否进行了准备工作。猴子到达的目标偶尔会在运动开始前跳跃位置，需要进行中游校正。在运动皮质和背侧运动前皮质，我们发现，发出何时到达信号的神经活动在逐一尝试的基础上预测猴子的跳跃反应。我们进一步识别神经模式，信号到达哪里，无论是在运动准备期间还是在运动执行期间。在目标跳跃后，神经活动在准备维度和与运动相关的维度上都会做出反应，即使那时准备维度上的误差可能很小。这表明，REACH矫正也涉及延迟REACH的准备过程。此外，它还表明电机准备和执行可以同时进行。
Motor preparation typically precedes movement and is thought to determine properties of upcoming movements. However, preparation has mostly been studied in point-to-point delayed reaching tasks. Here, we ask whether preparation is engaged during mid-reach modifications. Monkeys reach to targets that occasionally jump locations prior to movement onset, requiring a mid-reach correction. In motor cortex and dorsal premotor cortex, we find that the neural activity that signals when to reach predicts monkey's jump responses on a trial-by-trial basis. We further identify neural patterns that signal where to reach, either during motor preparation or during motor execution. After a target jump, neural activity responds in both preparatory and movement-related dimensions, even though error in preparatory dimensions can be small at that time. This suggests that the same preparatory process used in delayed reaching is also involved in reach correction. Furthermore, it indicates that motor preparation and execution can be performed simultaneously.