Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male rats.
Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male rats.
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DOI：
10.1016/j.ejphar.2008.07.002
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发表时间：
2008-09-11
影响因子：
5
通讯作者：
France, Charles P.
中科院分区：
文献类型：
--
作者：
Sevak, Rajkumar J.;Koek, Wouter;Owens, William Anthony;Galli, Aurelio;Daws, Lynette C.;France, Charles P.
关键词：
进食障碍和药物滥用的高共患病率表明，营养状况可以影响药物滥用的脆弱性。这些研究使用大鼠检查食物限制对纹状体多巴胺清除的影响，以及对安非他明（运动，条件性位置偏爱），多巴胺受体激动剂quinpirole（打哈欠）和多巴胺受体拮抗剂raclopride（僵住症）的行为影响。安非他明增加运动，并产生条件性位置偏好在自由进食和食物限制的大鼠。食物限制减少多巴胺的清除，这是恢复反复治疗安非他明或自由喂养。食物限制也降低了对喹吡罗引起的哈欠和雷氯普利引起的僵住症的敏感性;自由进食恢复了对这两种药物的正常敏感性。使多巴胺清除率正常化的相同安非他明治疗未能恢复对喹吡罗或雷氯必利的正常敏感性，这表明在食物限制的大鼠中，多巴胺转运体和多巴胺受体的活性受到安非他明刺激的通路的不同影响。这些研究表明，营养状况的适度变化显着改变多巴胺神经传递和直接作用的多巴胺受体药物（激动剂和拮抗剂）的行为效应。这些结果强调了营养状况的潜在重要性（例如，葡萄糖和胰岛素）调节多巴胺神经传递，并且在这样做时，它们开始在进食障碍和药物滥用的高共发病率之间建立神经化学联系。
The high comorbidity of eating disorders and substance abuse suggests that nutritional status can impact vulnerability to drug abuse. These studies used rats to examine the effects of food restriction on dopamine clearance in striatum and on the behavioral effects of amphetamine (locomotion, conditioned place preference), the dopamine receptor agonist quinpirole (yawning), and the dopamine receptor antagonist raclopride (catalepsy). Amphetamine increased locomotion and produced conditioned place preference in free-feeding and food-restricted rats. Food restriction reduced dopamine clearance, which was restored by repeated treatment with amphetamine or by free feeding. Food restriction also decreased sensitivity to quinpirole-induced yawning and raclopride-induced catalepsy; normal sensitivity to both drugs was restored by free feeding. The same amphetamine treatment that normalized dopamine clearance, failed to restore normal sensitivity to quinpirole or raclopride, suggesting that in food-restricted rats the activity of dopamine transporters and dopamine receptors is differentially affected by pathways that are stimulated by amphetamine. These studies show that modest changes in nutritional status markedly alter dopamine neurotransmission and the behavioral effects of direct-acting dopamine receptor drugs (agonist and antagonist). These results underscore the potential importance of nutritional status (e.g., glucose and insulin) in modulating dopamine neurotransmission and in so doing they begin to establish a neurochemical link between the high co-morbidity of eating disorders and drug abuse.
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DOI：
10.1186/1471-2210-6-6
发表时间：
2006-03-03
期刊：
BMC pharmacology
影响因子：
--
作者：
Han DD;Gu HH
通讯作者：
Gu HH
影响因子：
2.5
作者：
Amano, T;Matsubayashi, H;Sakai, N
通讯作者：
Sakai, N
影响因子：
4.7
作者：
Hilber, B;Scholze, P;Sitte, HH
通讯作者：
Sitte, HH
影响因子：
3.3
作者：
Carr, KD;Tsimberg, Y;Yamamoto, N
通讯作者：
Yamamoto, N
影响因子：
5.3
作者：
CILIAX, BJ;HEILMAN, C;LEVEY, AI
通讯作者：
LEVEY, AI