Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: Insight from oxygen-18 labeling experiments
Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: Insight from oxygen-18 labeling experiments
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DOI：
10.1002/anie.200500991
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发表时间：
2005-01-01
影响因子：
16.6
通讯作者：
Shafirovich, V
中科院分区：
文献类型：
--
作者：
Crean, C;Geacintov, NE;Shafirovich, V
（图中所示）在氧化应激条件下：鸟嘌呤和8-氧代-7，8-二氢鸟嘌呤的氧化已通过18 O-标记方法监测。核碱基自由基1与碳酸根阴离子2的结合导致O-从CO 3-的净转移。到最终产品（见图）。
(Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7, 8-dihydroguanine has been monitored by 18 O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O-from CO 3.-to the end products (see scheme).