Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a "mixed meal" in late pregnancy.
Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a "mixed meal" in late pregnancy.
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怀孕期间的碳水化合物代谢。
DOI：
10.1016/0026-0495(77)90050-6
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
Norbert Freinkel
中科院分区：
文献类型：
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作者：
Boyd E. Metzger;Roger H. Unger;Norbert Freinkel;Norbert Freinkel
研究了摄入含有碳水化合物（50 g）、蛋白质（25 g）和脂肪（10 g）的“混合膳食”后，妊娠期对循环葡萄糖、氨基酸、胰岛素和胰高血糖素变化的影响。9名受试者在妊娠30-40周和产后6-8周再次接受测试。“混合餐”在产前引起了更大且更长时间的血糖升高，而血清总氨基酸的增加在所有时间点都是钝化的。在血糖升高而胺源性刺激减少的情况下，产前血浆胰岛素的综合增加比产后高60%，而胰高血糖素的增加没有明显改变。因此，胰岛素/胰高血糖素综合反应在产前研究中增加。在混合营养物的食物刺激下，胰岛素的优势表明，在人类怀孕后期，摄入的氨基酸的合成代谢“促进”。
Gestational influences upon the changes in circulating glucose, amino acids, insulin, and glucagon after the ingestion of a “mixed meal” containing carbohydrate (50 g), protein (25 g), and fat (10 g) were examined. Nine subjects were tested during weeks 30–40 of gestation and again 6–8 wk postpartum. The “mixed meal” elicited greater and more prolonged increases in plasma glucose antepartum, whereas the increments in total serum amino acids were blunted at all time points. In the face of greater glycemic but lesser aminogenic stimulation, the integrated increase in plasma insulin was 60% greater antepartum than post partum, whereas the increment in glucagon was not significantly altered. Thus, integrated insulin/glucagon response was increased during antepartum studies. The insulin preponderance following alimentary challenge with mixed nutrients would suggest that the anabolism of ingested amino acids is “facilitated” during late human pregnancy.