Growth factors from platelets, monocytes, and endothelium: their role in cell proliferation.
Growth factors from platelets, monocytes, and endothelium: their role in cell proliferation.
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来自血小板、单核细胞和内皮的生长因子：它们在细胞增殖中的作用。
DOI：
10.1111/j.1749-6632.1982.tb43413.x
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发表时间：
1982
影响因子：
5.2
通讯作者：
Bowen-Pope,D
中科院分区：
文献类型：
--
作者：
Ross,R;Raines,E;Bowen-Pope,D
在本文开始时分配给生长因子的各种生物学作用中，这里描述的因子在很大程度上与对损伤的反应有关。这些代表了一种特殊类型的因子，因为它们中的两种，PDGF和MDGF，分别由血小板和单核细胞在循环中携带，因此可以被递送到增殖反应将是组织连续性恢复中的重要事件的部位。内皮源性生长因子在这些现象中的作用目前尚不清楚。动脉粥样硬化被认为是一种保护性增殖反应，这种反应已经出错并成为疾病。在这种情况下，PDGF和MDGF都可以发挥重要作用，因为血小板与早期损伤现象相关，巨噬细胞似乎存在于动脉粥样硬化病变发展的几乎所有阶段，从脂肪条纹到纤维斑块和复杂病变。在每一种情况下，巨噬细胞可能在病变进展和可能在病变起始中起重要作用。PDGF在某些病变的发生中也可能是重要的，并且在某些情况下无疑会参与血栓机化过程中发生的纤维增生反应。
Of the various biological roles assigned to growth factors at the beginning of this article, the factors described here are largely associated with the response to injury. These represent a special type of factor since two of them, PDGF and MDGF, are carried in the circulation by the platelet and the monocyte respectively, and can therefore be delivered to sites where a proliferative response would be an important event in the restitution of tissue continuity. The role of the endothelial-derived growth factor in these phenomena is not clear at present. Atherosclerosis has been suggested to represent a protective proliferative response that has gone awry and become disease. In this instance both PDGF and MDGF could play important roles, since platelets have been associated with the early injury phenomenon and macrophages appear to be present in virtually all phases of the development of the lesions of atherosclerosis from the fatty streak to the fibrous plaque and the complicated lesion. In each of these circumstances the macrophage may be important in lesion progression and possibly in lesion initiation. PDGF may also be important in initiation of some lesions, and in some instances would undoubtedly participate in the fibroproliferative response that occurs during organization of a thrombus.