Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results fromthe ICONIC study
Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results fromthe ICONIC study
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DOI：
10.1093/ehjci/jeaa210
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发表时间：
2021-01-01
影响因子：
6.2
通讯作者：
Andreini, Daniele
中科院分区：
文献类型：
--
作者：
Conte, Edoardo;Dwivedi, Aeshita;Andreini, Daniele
目的 尽管越来越多的证据支持通过冠状动脉计算机断层扫描血管造影（CCTA）评估冠状动脉粥样硬化，但没有关于定量斑块特征的年龄和性别差异的数据。本研究的目的是调查急性冠脉综合征 (ACS) 之前 CCTA 定性和定量动脉粥样硬化特征的性别和年龄差异。 方法和结果 在 ICONIC 研究中，234 名随后发生 ACS 的患者与 234 名非事件对照进行 1:1 倾向匹配，我们当前的子分析仅包括 ACS 病例。 CCTA 的定性和定量预先斑块分析均由核心实验室进行。在 129 例病例中，在 ACS 发生时通过侵入性冠状动脉造影确定的罪魁祸首病变与基线 CCTA 前体病变共同登记。然后根据性别和年龄将研究人群分为亚组（
Aims Although there is increasing evidence supporting coronary atherosclerosis evaluation by coronary computed tomography angiography (CCTA), no data are available on age and sex differences for quantitative plaque features. The aim of this study was to investigate sex and age differences in both qualitative and quantitative atherosclerotic features from CCTA prior to acute coronary syndrome (ACS).Methods and results Within the ICONIC study, in which 234 patients with subsequent ACS were propensity matched 1:1 with 234 non-event controls, our current subanalysis included only the ACS cases. Both qualitative and quantitative advance plaque analysis by CCTA were performed by a core laboratory. In 129 cases, culprit lesions identified by invasive coronary angiography at the time of ACS were co-registered to baseline CCTA precursor lesions. The study population was then divided into subgroups according to sex and age (