Clinical significance of antimonocyte antibody in kidney transplant recipients.
Clinical significance of antimonocyte antibody in kidney transplant recipients.
复制标题
肾移植受者抗单核细胞抗体的临床意义。
DOI：
10.1097/00007890-198112000-00009
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发表时间：
1981
期刊：
影响因子：
6.2
通讯作者：
M. E. DeFrancis
中科院分区：
文献类型：
--
作者：
G. Cerilli;L. Brasile;T. Galouzis;M. E. DeFrancis
单核细胞似乎包含一个抗原系统，与先前在血管内皮细胞（VEC）上发现的“细胞特异性”抗原系统非常相似。通过使用以单核细胞为靶细胞的交叉配型技术，我们测试了肾移植受者体内供体血管内皮细胞抗原抗体的存在，并进行了混合淋巴细胞培养，以及T和B细胞毒性测试。该技术在一些（活体相关的）供体-受体组合中检测到临床显著的致敏性，而标准T和B淋巴细胞技术无法检测到。单核细胞交叉配型阳性但T淋巴细胞或B淋巴细胞交叉配型阴性的患者发生严重排斥反应和移植物失败的发生率非常高。
Monocytes appear to contain an antigen system very similar to the "cell-specific" antigen system previously identified on the vascular endothelial cell (VEC). By using a crossmatch technique with monocytes as the target cell, we tested for the presence of antibody to donor vascular endothelial cell antigens in kidney transplantation recipients, as well as performed mixed lymphocyte cultures, and T and B cytotoxicity testing. This technique detected clinically significant sensitization in some (living related) donor-recipient combinations not detected with standard T and B lymphocyte techniques. Patients with positive monocyte crossmatches but negative T or B lymphocyte crossmatches have a very high incidence of severe rejection and graft failure.