Contribution of Toll-like receptor signaling to germinal center antibody responses.
Contribution of Toll-like receptor signaling to germinal center antibody responses.
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DOI：
10.1111/j.1600-065x.2012.01115.x
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发表时间：
2012-05
影响因子：
8.7
通讯作者：
Hou B
中科院分区：
文献类型：
--
作者：
DeFranco AL;Rookhuizen DC;Hou B
toll样受体（Toll-like receptor, TLRs）是引发炎症和促进适应性免疫反应的最重要的先天免疫受体家族之一。最近的研究已经检查了tlr促进抗体反应的能力，包括t细胞依赖性抗体反应。最初的研究表明，TLR刺激主要促进滤泡外抗体反应，该反应迅速产生由短寿命浆细胞产生的中等亲和力抗体。然而，最近的研究表明，tlr也可以增强生发中心反应，从而产生高亲和力的类转换抗体，这种抗体是由长寿的浆细胞产生的。TLR刺激可以增加后一种反应的强度，也可以增强对高亲和力IgG的选择。本文综述了TLRs在B细胞和其他细胞类型中增强抗体反应的作用的最新进展，重点介绍了t细胞依赖性和生发中心抗体反应。
Toll-like receptors (TLRs) have emerged as one of the most important families of innate immune receptors for initiating inflammation and also for promoting adaptive immune responses. Recent studies have examined the ability of TLRs to promote antibody responses, including T-cell-dependent antibody responses. Initial work suggested that TLR stimulation promotes primarily an extrafollicular antibody response, which rapidly produces moderate affinity antibodies made by short-lived plasma cells. Recent studies, however, have shown that TLRs also can enhance the germinal center response, which produces high affinity class-switched antibody made by long-lived plasma cells. TLR stimulation can increase the magnitude of the latter response and also enhance selection for high affinity IgG. This review summarizes recent advances in understanding the roles of TLRs in B cells and also in other cell types for enhancement of antibody responses, with an emphasis on T-cell-dependent and germinal center antibody responses.