LHRH‐PE40 Fusion Protein Tethered Silica Nanorattles for Imaging‐Guided Tumor‐Specific Drug Delivery and Bimodal Therapy
LHRH‐PE40 Fusion Protein Tethered Silica Nanorattles for Imaging‐Guided Tumor‐Specific Drug Delivery and Bimodal Therapy
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DOI：
10.1002/adma.201301217
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发表时间：
2013-10
影响因子：
29.4
通讯作者：
Fuping Gao;Linlin Li;Changhui Fu;Liya Nie;Dong Chen;Fangqiong Tang
中科院分区：
文献类型：
--
作者：
Fuping Gao;Linlin Li;Changhui Fu;Liya Nie;Dong Chen;Fangqiong Tang
Docyanine green (ICG) and LHRH-PE40 fusion protein are tethered onto drug carriers of silica nanorattles for imaging-guided tumor-specific drug delivery and bimodal therapy. The synergistic therapeutic effect of toxin PE40 and the chemotherapeutic drug docetaxel (Dtxl), specifically directed by LHRH to cancer, improves cancer treatment. Simultaneously, ICG enables real-time monitoring of the silica nanocomposites and therapeutic response.
