Effect of intrauterine growth restriction during late pregnancy on the growth performance, blood components, immunity and anti-oxidation capability of ovine fetus
Effect of intrauterine growth restriction during late pregnancy on the growth performance, blood components, immunity and anti-oxidation capability of ovine fetus
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妊娠晚期宫内生长受限对羊胎儿生长性能、血液成分、免疫及抗氧化能力的影响
DOI：
10.1016/j.livsci.2013.04.016
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发表时间：
2013-08-01
影响因子：
1.8
通讯作者：
Song, Shanshan
中科院分区：
文献类型：
--
作者：
Gao, Feng;Liu, Yingchun;Song, Shanshan
本研究探讨妊娠晚期宫内生长受限对绵羊胎儿生长性能、血液成分、免疫力和抗氧化能力的影响。在怀孕第90天宰杀36只蒙古母羊中的6只母羊作为初始对照组。其余29只动物被分配到三个不同的组：限制组1（RG1，0.18 MJ ME kg w（-0.75）d（-1），n = 12），限制组2（RG2，0.33 MJ ME kg w（-0.75）d（-1），n = 9）和对照组（CG，随意，0.67 MJ ME kg w（-0.75） d(-1)，n=8)。妊娠140 d时,每组抽取6名胎儿进行体重测量,采集脐带血进行血液成分、CD4(+)、CD8(+)T细胞、总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)分析。结果显示胎儿体重（P < 0.01）、体长（P < 0.05）、胸围（P < 0.05）、腹围（P < 0.05）、冠臀长（P < 0.01）、红细胞计数（P < 0.01）、血红蛋白（P < 0.01）、细胞压积（P < 0.01）、 CD4(+)和CD8(+) T细胞(P < 0.05)、T-AOC(P < 0.01)、SOD(P < 0.05)减少，平均血小板体积(P < 0.05)减少。
This study investigated the effect of intrauterine growth restriction on the growth performance, blood components, immunity and anti-oxidation capability of ovine fetus during late pregnancy. Six ewes out of 36 Mongolian ewes were slaughtered at d90 of pregnancy to serve as an initial comparison group. The remaining 29 animals were allocated to three different groups: Restricted Group1 (RG1, 0.18 MJ ME kg w(-0.75) d(-1), n=12), Restricted Group2 (RG2, 0.33 MJ ME kg w(-0.75) d(-1), n=9) and Control Group (CG, ad libitum, 0.67 MJ ME kg w(-0.75) d(-1), n=8). At 140 d of gestation, 6 fetuses in each groups were removed to determine the body weight, measurements and the umbilical cord blood was collected to analyze the blood components, CD4(+), CD8(+) T cells, total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA). The results indicated the fetal weight (P < 0.01), body length (P < 0.05), thoracic girth (P < 0.05), abdomen circumference (P < 0.05), curved crown-rump length (P < 0.01), red blood cell count (P < 0.01), hemoglobin (P < 0.01), packed cell volume (P < 0.01), CD4(+) and CD8(+) T cells (P < 0.05), T-AOC (P < 0.01), SOD (P < 0.05) were decreased and mean platelet volume (P