Lupus nephritis transcriptomics across space and time.
Lupus nephritis transcriptomics across space and time.
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跨越空间和时间的狼疮性肾炎转录组学。
DOI：
10.1016/j.kint.2022.06.028
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发表时间：
2022
影响因子：
19.6
通讯作者：
Alpers,CharlesE
中科院分区：
文献类型：
--
作者：
Jackson,ShaunW;Alpers,CharlesE
目前治疗狼疮肾炎的免疫抑制方案并不完全有效，使患者面临长期预后不良的风险。这强调需要剖析狼疮肾炎的致病机制，以告知靶向治疗的发展。在这一期的《肾脏国际》杂志上，Parikhet等人对治疗前和治疗后的肾脏活检进行了转录组学分析，将其分为肾小球和小管间质室，以确定区分治疗反应和无反应的候选分子途径。
Current immunosuppression regimens for lupus nephritis are incompletely effective, placing patients at risk for poor long-term outcomes. This emphasizes the need to dissect pathogenic mechanisms in lupus nephritis, to inform the development of targeted therapies. In this issue of Kidney International, Parikhet al.performed transcriptomic analysis of pretreatment and posttreatment protocol kidney biopsies, segregated into glomerular and tubulointerstitial compartments, to identify candidate molecular pathways distinguishing treatment responders and nonresponders.