The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation.
The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation.
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DOI：
10.3389/fimmu.2021.765034
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发表时间：
2021
影响因子：
7.3
通讯作者：
Burgdorf S
中科院分区：
文献类型：
--
作者：
van der Zande HJP;Nitsche D;Schlautmann L;Guigas B;Burgdorf S
甘露糖受体是C型凝集素(CLEC)家族的一员，可以结合和内化多种内源性和病原体相关的配体。由于这些特性，它在内吞作用以及抗原处理和提呈中的作用已被深入研究。最近发现，甘露糖受体可以直接影响多种免疫细胞的激活。由抗原呈递细胞表达的结合细胞的甘露糖受体确实被证明能驱动激活的T细胞向耐受表型转变。另一方面，据报道，在患有各种炎症性疾病的患者中，血清中一种可溶性甘露糖受体的浓度会增加，并与疾病的严重程度有关。有趣的是，我们最近证明，可溶性甘露糖受体直接促进巨噬细胞的促炎活化和触发代谢。在这篇综述中，我们强调了甘露糖受体和其他CLECs在调节免疫细胞激活和形成炎症反应中的作用。
The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and internalize a variety of endogenous and pathogen-associated ligands. Because of these properties, its role in endocytosis as well as antigen processing and presentation has been studied intensively. Recently, it became clear that the mannose receptor can directly influence the activation of various immune cells. Cell-bound mannose receptor expressed by antigen-presenting cells was indeed shown to drive activated T cells towards a tolerogenic phenotype. On the other hand, serum concentrations of a soluble form of the mannose receptor have been reported to be increased in patients suffering from a variety of inflammatory diseases and to correlate with severity of disease. Interestingly, we recently demonstrated that the soluble mannose receptor directly promotes macrophage proinflammatory activation and trigger metaflammation. In this review, we highlight the role of the mannose receptor and other CLECs in regulating the activation of immune cells and in shaping inflammatory responses.
影响因子：
11.1
作者：
Wu, Xinle;Zhang, Jun;Ge, Hongfei;Gupte, Jamila;Baribault, Helene;Lee, Ki Jeong;Lemon, Bryan;Coberly, Suzanne;Gong, Yan;Pan, Zheng;Rulifson, Ingrid C.;Gardner, Jonitha;Richards, William G.;Li, Yang
通讯作者：
Li, Yang