PERIVENTRICULAR VENOUS COLLAGENOSIS - ASSOCIATION WITH LEUKOARAIOSIS
PERIVENTRICULAR VENOUS COLLAGENOSIS - ASSOCIATION WITH LEUKOARAIOSIS
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DOI：
10.1148/radiology.194.2.7824728
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发表时间：
1995-02-01
期刊：
影响因子：
19.7
通讯作者：
ANDERSON, RL
中科院分区：
文献类型：
--
作者：
MOODY, DM;BROWN, WR;ANDERSON, RL
目得：为了探讨年龄相关的室管膜下静脉退行性疾病和leukoaraiois.MATERIALS和方法之间的关联：从22例（平均年龄，73.2岁，范围，25-95岁）尸检获得的大脑进行了检查与磁共振（MR）成像和神经病理学方法与碱性磷酸酶微血管染色。脑白质疏松症的程度上显示的MR图像和深静脉闭塞进行了独立的评分和结果与Logistic回归analysis.Results：非炎症性胶原增厚的静脉壁导致严重的脑室周围静脉狭窄被发现在13（65%）的20例60岁以上。13例患者中有10例（77%）发现晚期脑白质疏松症。更大的静脉疾病与更严重的leukoaraiois.CONCLUSION：脑室周围静脉胶原病，一种常见的和以前被忽视的老年人退行性疾病，是与leukoaraiois. CONCLUSION密切相关。脑深静脉狭窄或闭塞可促进脑白质疏松症的发展。
PURPOSE: To investigate the association between an age-related degenerative disease of subependymal veins and leukoaraiosis.MATERIALS AND METHODS: Brains obtained at autopsy from 22 patients (average age, 73.2 years; range, 25-95 years) were examined with magnetic resonance (MR) imaging and neuropathologic methods with alkaline phosphatase microvascular staining. The degrees of leukoaraiosis shown on MR images and of deep venous occlusion were scored independently and results compared with logistic regression analysis.RESULTS: Noninflammatory collagenous thickening of venous walls resulting in severe periventricular venous stenosis was found in 13 (65%) of 20 patients over 60 years old. Advanced leukoaraiosis was found in 10 (77%) of these 13 patients. Greater venous disease was associated with more severe leukoaraiosis.CONCLUSION: Periventricular venous collagenosis, a commonly observed and previously ignored degenerative disease of elderly humans, is strongly associated with leukoaraiosis. Stenosis or occlusion of deep cerebral veins may promote development of leukoaraiosis.