Translation of Patient-Reported Outcomes in Oncology Clinical Trials to Everyday Practice
Translation of Patient-Reported Outcomes in Oncology Clinical Trials to Everyday Practice
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DOI：
10.1245/s10434-019-07749-2
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发表时间：
2020-01-01
影响因子：
3.7
通讯作者：
Schrag, Deborah
中科院分区：
文献类型：
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作者：
Ivatury, Srinivas Joga;Hazard-Jenkins, Hannah W.;Schrag, Deborah
目的.评价患者报告结局（PRO）收集效果的肿瘤学临床试验发现，使用PRO监测症状与通过减少急性护理利用和降低患者症状负担改善临床护理相关。这篇教育综述将评估系统的PRO整合到日常肿瘤临床实践中的策略。我们概述了在临床实践中使用PRO的关键考虑因素，强调了来自已发表研究的证据。我们还讨论了PRO在肿瘤学中实施的好处和挑战。在临床实践中实施PRO收集可以改善护理服务，促进以患者为中心的临床研究。在临床实践中使用PRO的考虑因素包括仪器的选择、输送方法和查询频率。实施系统性PRO收集的挑战包括实施所需的成本和资源、对临床工作流程的影响以及控制/监测医生倦怠。虽然在财政资源和工作人员参与/倦怠方面存在挑战，但临床实践中的患者报告结果提供了许多好处，包括症状监测，临床研究和潜在的实时个性化临床决策支持。
Purpose. Clinical trials in oncology evaluating the effects of patient-reported outcomes (PRO) collection have found that monitoring of symptoms with PROs is associated with improved clinical care through reduced acute care utilization and decreased patient symptom burden. This educational review will evaluate strategies for systematic PRO integration into everyday oncology clinical practice.Methods. We outline key considerations for using PROs in clinical practice, highlighting evidence from published studies. We also discuss the benefits and challenges of PRO implementation in oncology.Results. Implementing PRO collection in clinical practice can improve care delivery and facilitate patient-centered clinical research. Considerations for using PROs in clinical practice include choice of instrument, method of delivery, and frequency of query. Challenges with implementing systematic PRO collection include the costs and resources needed for implementation, impact on clinical workflow, and controlling/monitoring physician burnout.Conclusions. While challenges exist in terms of financial resources and staff participation/burnout, patient-reported outcomes in clinical practice provide a number of benefits, including symptom monitoring, clinical research, and potential real-time personalized clinical-decision support.