Lens Opacity and Hydrogen Sulfide in a New Zealand Geothermal Area.
Lens Opacity and Hydrogen Sulfide in a New Zealand Geothermal Area.
复制标题
DOI：
10.1097/opx.0000000000001049
复制
发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Garrett N
中科院分区：
文献类型：
--
作者：
Bates MN;Bailey IL;DiMartino RB;Pope K;Crane J;Garrett N
硫化氢（H2S）是一种高度有毒的气体，对眼睛有明确的急性刺激作用。新西兰罗托鲁瓦的人口位于活跃的地热田上，是世界上环境H2S暴露最高的地区之一。罗托鲁瓦生态研究的证据表明，H2S与白内障有关。本研究的目的是，使用更详细的曝光表征，临床检查和前眼摄影，更直接地调查这种先前报道的关联。从罗托鲁瓦综合初级保健医疗登记处登记了1637名年龄在18-65岁的成年人。患者接受了全面的眼科检查，包括瞳孔扩张和透镜摄影，以捕获任何核混浊、核颜色以及皮质和后囊下混浊的证据。在LOCS III量表上对所有四种结局的照片进行评分，并在样本之间进行十进制插值。根据罗托鲁瓦各地的被动采样器网络以及30年来对住宅、工作场所和学校地点的了解，估计了过去30年的H2S暴露。使用线性和逻辑回归的数据分析检查了混浊程度和核颜色或白内障（定义为LOCS III评分≥ 2.0）与H2S暴露之间的相关性。估计的H2S暴露与四种眼科结局指标中的任何一种之间均无相关性。总体而言，结果总体上令人放心。他们没有提供证据表明罗托鲁瓦发现的H2S暴露水平与白内障有关。先前发现的罗托鲁瓦人口白内障和硫化氢暴露之间的关联似乎可能是由于生态研究设计的局限性。这些结果不能排除在较高水平的硫化氢暴露下与白内障相关的可能性。
Hydrogen sulfide (H2S) is a highly toxic gas with well-established, acute irritation effects on the eye. The population of Rotorua, New Zealand, sited on an active geothermal field has some of the highest ambient H2S exposures in the world. Evidence from ecological studies in Rotorua has suggested that H2S is associated with cataract. The purpose of the present study was, using more detailed exposure characterization, clinical examinations and anterior eye photography, to more directly investigate this previously reported association. Enrolled were 1637 adults, ages 18–65, from a comprehensive Rotorua primary care medical register. Patients underwent a comprehensive ophthalmic examination, including pupillary dilation and lens photography to capture evidence of any nuclear opacity, nuclear color, and cortical and posterior subcapsular opacity. Photographs were scored for all four outcomes on the LOCS III scale with decimalized interpolation between the exemplars. H2S exposure for up to the last 30 years was estimated based on networks of passive samplers set out across Rotorua and knowledge of residential, workplace and school locations over the 30 years. Data analysis using linear and logistic regression examined associations between the degree of opacification and nuclear color or cataract (defined as a LOCS III score ≥ 2.0) in relation to H2S exposure. No associations were found between estimated H2S exposures and any of the four ophthalmic outcome measures. Overall, results were generally reassuring. They provided no evidence that H2S exposure at the levels found in Rotorua is associated with cataract. The previously found association between cataract and H2S exposure in the Rotorua population seems likely to be attributable to the limitations of the ecological study design. These results cannot rule out the possibility of an association with cataract at higher levels of H2S exposure.