A MORBILLIVIRUS THAT CAUSED FATAL DISEASE IN HORSES AND HUMANS
A MORBILLIVIRUS THAT CAUSED FATAL DISEASE IN HORSES AND HUMANS
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DOI：
10.1126/science.7701348
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发表时间：
1995-04-07
期刊：
影响因子：
56.9
通讯作者：
KETTERER, P
中科院分区：
文献类型：
--
作者：
MURRAY, K;SELLECK, P;KETTERER, P
麻疹病毒已经被分离出来，并被添加到越来越多的新兴病毒性疾病的名单中。这种病毒引起了马和人类致命呼吸道疾病的爆发。遗传分析表明，它与经典的麻疹病毒牛瘟、麻疹和犬瘟热只有远亲关系。当用电子显微镜观察时，病毒有10纳米和18纳米的表面突起，使它们看起来像“双条纹”。这种病毒诱导了在血管内皮，特别是肺内皮中发育的合胞体。
A morbillivirus has been isolated and added to an increasing list of emerging viral diseases. This virus caused an outbreak of fatal respiratory disease in horses and humans. Genetic analyses show it to be only distantly related to the classic morbilliviruses rinderpest, measles, and canine distemper. When seen by electron microscopy, viruses had 10- and 18-nanometer surface projections that gave them a ''double-fringed'' appearance. The virus induced syncytia that developed in the endothelium of blood vessels, particularly the lungs.