Two Fatalities Involving Mebroqualone.
Two Fatalities Involving Mebroqualone.
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DOI：
10.1093/jat/bkaa077
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发表时间：
2020-08
影响因子：
2.5
通讯作者：
K. M. Woods
中科院分区：
文献类型：
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作者：
K. M. Woods
甲溴喹酮是甲喹酮的类似物，关于这种特制药物的毒性，发表的信息很少。我们描述了两个案件与非致命水平的甲喹酮在尸检收集的血液。病例1是一起涉及房屋火灾的意外死亡，发现死者血液中甲溴喹酮浓度为10，228 ng/mL。病例2为火车自杀未遂者，发现死者血药浓度为115 ng/mL。据我们所知，这是科学文献中第一份比较两种死后甲溴喹酮血液浓度的报告。采用简单的液-液萃取法从尸体血液中提取甲喹酮，并通过气相色谱-质谱法进行分析。
Mebroqualone is an analogue of methaqualone, and there is a very little published information regarding the toxicity of this designer drug. We describe two cases with non-lethal levels of mebroqualone in blood collected at autopsy. Case 1 was an accidental death that involved a house fire, and the decedent was found to have a blood mebroqualone concentration of 10,228 ng/mL. Case 2 was a completed suicide by train, and the decedent was found to have a blood concentration of 115 ng/mL. To our knowledge, this is the first report in the scientific literature to compare two postmortem blood concentrations of mebroqualone. Mebroqualone was extracted from postmortem blood using a simple liquid-liquid extraction procedure and analyzed via gas chromatography-mass spectrometry.