Fat Mass Loss Predicts Gain in Physical Function With Intentional Weight Loss in Older Adults
Fat Mass Loss Predicts Gain in Physical Function With Intentional Weight Loss in Older Adults
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DOI：
10.1093/gerona/gls092
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发表时间：
2013-01-01
影响因子：
5.1
通讯作者：
Krichevsky, Stephen B.
中科院分区：
文献类型：
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作者：
Beavers, Kristen M.;Miller, Michael E.;Krichevsky, Stephen B.
背景。老年人减肥（WL）的临床建议仍然存在争议，部分原因是对瘦体重减少和潜在身体功能丧失的担忧。本研究的目的是确定接受有意 WL 的老年人、超重和肥胖成年人的脂肪和瘦体重变化与身体机能变化之间的独立关联。合并了三项随机对照试验的数据，这些试验针对具有相似功能结果（短期身体表现电池和 Pepper 残疾评估工具）的老年人进行有意 WL。协方差模型分析用于研究体重、脂肪和瘦体重的变化（使用双能 X 射线吸收测定法获得）与身体机能变化之间的关系。结果。总体体重减轻为-7.8 +/- 6.1 kg（脂肪和瘦肉质量分别为-5.6 +/- 4.1 kg和-2.7 +/- 2.4 kg）。在所有研究中，在调整年龄、性别和身高后，总体 WL 与自我报告的行动障碍 (p < .01) 和步行速度 (p < .01) 的显着改善相关。将脂肪和瘦肉质量的变化作为自变量的模型发现，只有脂肪质量的变化才能显着预测行动障碍（beta[fat] = 0.04；p < .01）和步行速度（beta[fat] = -0.01；p < .01）的变化。结论。这项研究的结果表明，有意识的WL后体重减轻与超重和肥胖老年人自我报告的行动障碍和步行速度的显着改善相关。重要的是，人们发现脂肪量的减少比瘦肉量的减少更能预测身体机能的变化。
Background. Clinical recommendation of weight loss (WL) in older adults remains controversial, partially due to concerns regarding lean mass loss and potential loss of physical function. The purpose of this study is to determine the independent associations between changes in fat and lean mass and changes in physical function in older, overweight, and obese adults undergoing intentional WL.Methods. Data from three randomized-controlled trials of intentional WL in older adults with similar functional outcomes (short physical performance battery and Pepper assessment tool for disability) were combined. Analyses of covariance models were used to investigate relationships between changes in weight, fat, and lean mass (acquired using dual-energy x-ray absorptiometry) and changes in physical function.Results. Overall loss of body weight was -7.8 +/- 6.1 kg (-5.6 +/- 4.1 kg and -2.7 +/- 2.4 kg of fat and lean mass, respectively). In all studies combined, after adjustment for age, sex, and height, overall WL was associated with significant improvements in self-reported mobility disability (p < .01) and walking speed (p < .01). Models including change in both fat and lean mass as independent variables found only the change in fat mass to significantly predict change in mobility disability (beta[fat] = 0.04; p < .01) and walking speed (beta[fat] = -0.01; p < .01).Conclusions. Results from this study demonstrate that loss of body weight, following intentional WL, is associated with significant improvement in self-reported mobility disability and walking speed in overweight and obese older adults. Importantly, fat mass loss was found to be a more significant predictor of change in physical function than lean mass loss.