Is invasive lobular carcinoma different from invasive ductal carcinoma?
Is invasive lobular carcinoma different from invasive ductal carcinoma?
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DOI：
10.1053/ejso.2002.1423
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发表时间：
2003-05-01
期刊：
影响因子：
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通讯作者：
Berberoglu, U
中科院分区：
文献类型：
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作者：
Mersin, H;Yildirim, E;Berberoglu, U
目的：本研究的目的是确定是否在浸润性小叶癌（ILC）和浸润性导管癌（IDC）的组织病理学特征和结果是不同的，以及是否组织学类型是一个预后因素outcome.Methods：回顾性队列研究进行了连续5 - 10阶段I/II乳腺癌患者进行改良根治术。将65例ILC与445例IDC的临床特征进行比较。结果：ILC和IDC患者的中位年龄分别为52岁和41岁（P = 0.04）。肿瘤大小、雌激素受体阳性表达和淋巴结阳性率在不同组织学类型之间无显著差异。ILC原发灶中低度恶性肿瘤占81.5%，淋巴管侵犯占9.3%，明显高于IDC（P < 0.05）。ILC和IDC的5年总生存率分别为94%和90%，5年无事件生存率分别为71%和67%（P = NS）。多变量分析。所有患者均证实肿瘤大小、病理淋巴结状态和诊断时的年龄是总体和无事件生存的最重要预后因素。组织学类型无统计学意义的两个outcome.Conclusions：虽然ILC患者的年龄较大，低级别的肿瘤和淋巴管浸润较少，他们没有生存优势相比，他们的同行。组织学类型不是一个独立的预后因素。(C)2003爱思唯尔科技有限公司版权所有。
Aims: The purpose of this study is to determine whether the histopathologic features and outcome in invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) are different, and whether the histologic type is a prognostic factor for outcome.Methods: A retrospective cohort study was conducted in consecutive 5 10 stage I/II breast carcinoma patients who underwent modified radical mastectomy. The features of 65 patients with ILC were compared with those of 445 patients with IDC. In patients with median follow-up period of 44 months, univariate and multivariate prognostic factor analyses for cancer-specific death and relapse were carried out.Results: The median ages in patients with ILC and those with IDC were 52 and 41 (P = 0.04). Tumor size, estrogen receptor positive expression and nodal positivity were not significantly different between the histologic types. Patients with ILC had more frequently (81.5%) low grade tumors and less lymphatic vascular invasion (9.3%) in primary tumor than those with IDC (P < 0.05). Whereas the rates of 5-year overall survival were 94% in ILC and 90% in IDC, the rates of 5-year event-free survival were 71 and 67%, respectively (P = NS). Multivariate analyses in. all patients demonstrated that tumor size, pathologic lymph node status and age at diagnosis were the most important prognostic factors for overall and event-free survival. Histologic type was not statistically significant for both outcomes.Conclusions: Although patients with ILC had older age, low grade tumor and less lymphatic vascular invasion, they had no survival advantage comparing with their counterparts. Histologic type was not an independent prognostic factor for outcome. (C) 2003 Elsevier Science Ltd. All rights reserved.