Immune Microenvironment in Glioblastoma Subtypes.
Immune Microenvironment in Glioblastoma Subtypes.
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DOI：
10.3389/fimmu.2018.01004
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发表时间：
2018
影响因子：
7.3
通讯作者：
Hambardzumyan D
中科院分区：
文献类型：
--
作者：
Chen Z;Hambardzumyan D
胶质母细胞瘤（GBM）是最常见和最具侵袭性的原发性脑肿瘤。由于其恶性生长和侵入脑实质，再加上对治疗的抵抗力，GBM是所有癌症中最致命的癌症之一。GBM在分子和组织学水平上都是高度异质性的。标志性组织学结构包括假性扁平坏死和微血管增生。除了高水平的肿瘤内异质性之外，GBM还表现出高水平的肿瘤间异质性。GBM微环境中的主要非肿瘤细胞群包括称为肿瘤相关巨噬细胞（TAM）的先天免疫系统细胞。来自文献的相关数据表明，分子上不同的GBM亚型在其微环境中表现出差异。GBM小鼠模型的数据表明，遗传驱动突变可以创造独特的微环境。在这里，我们回顾的起源，特点和功能的TAM在不同的GBM亚型。我们还讨论了它们与其他免疫细胞成分的相互作用，并讨论了治疗靶向TAM以提高T细胞功能功效的前景。
Glioblastomas (GBMs) are the most common and aggressive primary brain tumors. Due to their malignant growth and invasion into the brain parenchyma coupled with resistance to therapy, GBMs are among the deadliest of all cancers. GBMs are highly heterogeneous at both the molecular and histological levels. Hallmark histological structures include pseudopalisading necrosis and microvascular proliferation. In addition to high levels of intratumoral heterogeneity, GBMs also exhibit high levels of inter-tumoral heterogeneity. The major non-neoplastic cell population in the GBM microenvironment includes cells of the innate immune system called tumor-associated macrophages (TAMs). Correlative data from the literature suggest that molecularly distinct GBM subtypes exhibit differences in their microenvironment. Data from mouse models of GBM suggest that genetic driver mutations can create unique microenvironments. Here, we review the origin, features, and functions of TAMs in distinct GBM subtypes. We also discuss their interactions with other immune cell constituents and discuss prospects of therapeutically targeting TAMs to increase the efficacy of T-cell functions.
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影响因子：
--
作者：
Filley AC;Henriquez M;Dey M
通讯作者：
Dey M
影响因子：
3.7
作者：
Brennan C;Momota H;Hambardzumyan D;Ozawa T;Tandon A;Pedraza A;Holland E
通讯作者：
Holland E
DOI：
10.1084/jem.20141539
发表时间：
2015-04-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dal-Secco D;Wang J;Zeng Z;Kolaczkowska E;Wong CH;Petri B;Ransohoff RM;Charo IF;Jenne CN;Kubes P
通讯作者：
Kubes P
影响因子：
11.2
作者：
Fecci, PE;Mitchell, DA;Sampson, JH
通讯作者：
Sampson, JH
影响因子：
3.7
作者：
Engler JR;Robinson AE;Smirnov I;Hodgson JG;Berger MS;Gupta N;James CD;Molinaro A;Phillips JJ
通讯作者：
Phillips JJ