Clinical Effectiveness of Maintenance Electroconvulsive Therapy in Patients with Schizophrenia: A Retrospective Cohort Study.
Clinical Effectiveness of Maintenance Electroconvulsive Therapy in Patients with Schizophrenia: A Retrospective Cohort Study.
复制标题
精神分裂症患者维持电惊厥治疗的临床疗效：一项回顾性队列研究。
DOI：
10.1097/yct.0000000000000613
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Blumberger,DanielM
中科院分区：
文献类型：
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作者：
Isserles,Moshe;Remington,Jesse;Kaster,TylerS;Daskalakis,ZafirisJ;Blumberger,DanielM
本研究旨在评估维持性电休克治疗（mECT）对精神分裂症或情感性精神障碍患者的临床疗效和认知功能的影响，并探讨与这两种结果相关的因素。我们用精神疾病诊断和统计手册检查了47名患者的临床记录，（第四版）2010年4月至2016年7月期间在学术精神健康医院接受mECT治疗的精神分裂症或情感障碍的诊断。对62个无抽搐电休克疗法课程进行了审查。我们评估了临床疗效和认知效果以及与治疗反应相关的因素，包括精神病诊断，伴随药物治疗，和以前的治疗respons.ResultsMaintenance电休克治疗能够维持48（77%）疗程的临床反应。7个疗程（11%）报告了显著的认知不良反应。使用抗精神病药，抗抑郁药或苯二氮卓类药物，精神疾病，和性别与responsibility.ConclusionThis研究显示有意义的临床疗效和良好的耐受性mECT在长期耐药精神分裂症患者。
ObjectiveThis study aimed to assess the clinical effectiveness and cognitive effects of maintenance electroconvulsive therapy (mECT) in patients with schizophrenia or schizoaffective disorder and explore factors associated with both outcomes.MethodsIn this retrospective cohort study, we examined clinical records of 47 patients with a Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) diagnosis of schizophrenia or schizoaffective disorder treated with mECT at an academic mental health hospital between April 2010 and July 2016. Sixty-two mECT courses were reviewed. We assessed clinical effectiveness and cognitive effects as well as factors associated with response to treatment, including psychiatric diagnosis, concomitant pharmacological treatment, and previous treatment response.ResultsMaintenance electroconvulsive therapy was able to maintain clinical response in 48 (77%) treatment courses. Significant cognitive adverse effects were reported in 7 (11%) of the courses. Use of antipsychotic, antidepressant or benzodiazepine medications, psychiatric disorder, and sex were not associated with response.ConclusionThis study shows meaningful clinical effectiveness and good tolerability of mECT in patients with resistant schizophrenia over extended periods.