THE RELATION OF RADIONUCLIDE UPTAKE BY BONE TO THE RATE OF CALCIUM MINERALIZATION .1. EXPERIMENTAL STUDIES USING CA-45, P-32 AND TC-99M-MDP
THE RELATION OF RADIONUCLIDE UPTAKE BY BONE TO THE RATE OF CALCIUM MINERALIZATION .1. EXPERIMENTAL STUDIES USING CA-45, P-32 AND TC-99M-MDP
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DOI：
10.1259/0007-1285-62-736-314
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发表时间：
1989-04-01
影响因子：
2.6
通讯作者：
HARE, WSC
中科院分区：
文献类型：
--
作者：
BUDD, RS;HODGSON, GS;HARE, WSC
本文用~（45）Ca、~（32）P和常规骨显像剂~（99）mTc-MDP，在小鼠移植尾骨模型上研究了骨对放射性核素的摄取。该模型提供了一个实验系统，其中钙矿物质含量和矿化速率都在其整个发育过程中逐渐变化。45 Ca和32 P的吸收与钙矿化速率呈显著的线性相关关系，这一关系在嫁接体生长的各个阶段都是成立的。因此，两种放射性示踪剂都准确地反映了钙矿物质沉积。在99 mTc-MDP的情况下，与矿化率的相关性仅适用于最活跃的生长期的接枝时，速率增加。对于所有放射性示踪剂，骨摄取的峰值对应于矿化率的最大值。
The study of the uptake of radionuclides by bone has been undertaken in a mouse tail graft model using 45Ca, 32P and a routine bone scanning agent 99mTc-MDP, together with serial calcium determinations. The model provided an experimental system in which the calcium mineral content and the rate of mineralization both changed progressively throughout its development. A significant linear correlation was found between 45Ca and 32P uptake and the rate of calcium mineralization, which held for all stages of the graft''s growth. Both radiotracers therefore accurately reflected the calcium mineral deposition. In the case of 99mTc-MDP, the correlation with mineralization rate only applied for the most active growth period of the graft when the rate was increasing. For all radiotracers, the peak in bone uptake corresponded to the maximum in mineralization rate.