Myocardial Tissue Characterization Using Magnetic Resonance Noncontrast T1 Mapping in Hypertrophic and Dilated Cardiomyopathy
Myocardial Tissue Characterization Using Magnetic Resonance Noncontrast T1 Mapping in Hypertrophic and Dilated Cardiomyopathy
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DOI：
10.1161/circimaging.112.976738
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发表时间：
2012-11-01
影响因子：
7.5
通讯作者：
Neubauer, Stefan
中科院分区：
文献类型：
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作者：
Dass, Sairia;Suttie, Joseph J.;Neubauer, Stefan
背景-非对比磁共振T1成像反映了细胞内和细胞外信号的复合。我们假设，noncontrast T1映射可以表征心肌超越所取得的成熟的晚期钆增强（LGE）技术（检测局灶性纤维化）在肥厚型（HCM）和扩张型（DCM）心肌病，通过检测弥漫性和局灶性fibrosis.Methods和Results-Subjects进行心血管磁共振成像在3T（28 HCM，18 DCM，和12正常）。获取匹配的短轴切片用于电影、T1标测和LGE成像（0.1 mmol/kg）。测量室中切面的周向应变，并采集室中切面间隔的P-31磁共振波谱。平均T1弛豫时间在HCM和DCM中增加（HCM 1209 +/-28 ms，DCM 1225 +/-42 ms，正常1178 +/-13 ms，P
Background-Noncontrast magnetic resonance T1 mapping reflects a composite of both intra-and extracellular signal. We hypothesized that noncontrast T1 mapping can characterize the myocardium beyond that achieved by the well-established late gadolinium enhancement (LGE) technique (which detects focal fibrosis) in both hypertrophic (HCM) and dilated (DCM) cardiomyopathy, by detecting both diffuse and focal fibrosis.Methods and Results-Subjects underwent Cardiovascular Magnetic Resonance imaging at 3T (28 HCM, 18 DCM, and 12 normals). Matching short-axis slices were acquired for cine, T1 mapping, and LGE imaging (0.1 mmol/kg). Circumferential strain was measured in the midventricular slice, and P-31 magnetic resonance spectroscopy was acquired for the septum of the midventricular slice. Mean T1 relaxation time was increased in HCM and DCM (HCM 1209 +/- 28 ms, DCM 1225 +/- 42 ms, normal 1178 +/- 13 ms, P