THE EFFECT OF HALOTHANE ON MICE SELECTIVELY BRED FOR DIFFERENTIAL SENSITIVITY TO ALCOHOL
THE EFFECT OF HALOTHANE ON MICE SELECTIVELY BRED FOR DIFFERENTIAL SENSITIVITY TO ALCOHOL
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DOI：
10.1016/0091-3057(80)90150-1
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发表时间：
1980-01-01
影响因子：
3.6
通讯作者：
DEITRICH, R
中科院分区：
文献类型：
--
作者：
BAKER, R;MELCHIOR, C;DEITRICH, R
研究了小鼠对氟烷的反应。小鼠对乙醇的麻醉作用有选择性地敏感（长睡眠，LS）或抵抗（短睡眠，SS）。虽然观察到动物对乙醇的反应在睡眠时间、觉醒时血液麻醉剂浓度和体温方面存在很大差异，但SS系和LS系对氟烷的反应没有差异。乙醇和氟烷的作用机理彼此之间有很大的不同。
The response of mice to halothane was studied. Mice were selectively bred for either sensitivity (long sleep, LS) or resistance (short sleep, SS) to the anesthetic effects of ethanol. While large differences in the response of the animals to ethanol were observed in sleep time, blood anesthetic concentration at time of awakening, and body temperature, the SS and LS lines did not differ in their response to halothane. The mechanism of action of ethanol and halothane differ in a significant way from each other.