Ultrasmall T1-T2 Magnetic Resonance Multimodal Imaging Nanoprobes for the Detection of β-amyloid Aggregates in Alzheimer's Disease Mice
Ultrasmall T1-T2 Magnetic Resonance Multimodal Imaging Nanoprobes for the Detection of β-amyloid Aggregates in Alzheimer's Disease Mice
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超小型 T-1-T-2 磁共振多模态成像纳米探针用于检测阿尔茨海默病小鼠中的 β-淀粉样蛋白聚集体
DOI：
10.1021/acsami.0c01597
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发表时间：
2020-06-17
影响因子：
9.5
通讯作者：
Li, Li
中科院分区：
文献类型：
--
作者：
Cai, Jing;Yi, Peiwei;Li, Li
阿尔茨海默病（AD）是一种不可逆的脑部疾病，给患者和公共卫生系统带来了严重的负担。大多数研究工作都集中在寻找有效的治疗药物，但现在是时候追求有效的早期诊断的基础上，合理的假设，AD可能更容易预防比逆转。最近的研究表明，有几种探针用于检测淀粉样蛋白β（A β）斑块，这是AD脑中发现的神经病理学标志之一。然而，利用高空间分辨率的脑成像技术对A β斑块进行非放射性、灵敏的检测和定位仍然是一个巨大的挑战。本文中，吩噻嗪衍生物（PZD）缀合的亚5 nm超小铁氧体纳米探针（UFNPs@PEG/PZD）被设计和制备用于A β斑块的有效T-1 -T-2磁共振多模态成像。UFNPs@PEG/PZD不仅具有与A β斑块的高亲和力，而且具有优良的r（1）和r（2）弛豫特性。因此，这项研究提供了一个有前途的超小纳米平台作为A β靶向的多模态成像探针，用于AD的早期诊断。
Alzheimer's disease (AD) is an irreversible brain disorder and imposes a severe burden upon patients and the public health system. Most research efforts have focused on the search for effective therapeutic drugs, but it is time to pursue efficient early diagnosis based on the reasonable assumption that AD may be easier to prevent than reverse. Recent studies have shown that there are several probes for detecting amyloid-beta (A beta) plaques, one of the neuropathological hallmarks found in AD brain. However, it is still a great challenge for nonradioactive, sensitive detection and location of A beta plaques by brain imaging with high spatial resolution. Herein, phenothiazine derivative (PZD)-conjugated sub-5 nm ultrasmall ferrite nanoprobes (UFNPs@PEG/PZD) are designed and prepared for efficient T-1 -T-2 magnetic resonance multimodal imaging of A beta plaques. UFNPs@PEG/PZD not only possess high binding affinity to A beta plaques but also exhibit excellent properties of r(1) and r(2) relaxivities. This study thus provides a promising ultrasmall nanoplatform as an A beta-targeting multimodal imaging probe for the application of early diagnosis of AD.