Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
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DOI：
10.1016/j.immuni.2013.08.028
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发表时间：
2013-10-17
期刊：
影响因子：
32.4
通讯作者：
Medzhitov R
中科院分区：
文献类型：
--
作者：
Gao Y;Nish SA;Jiang R;Hou L;Licona-Limón P;Weinstein JS;Zhao H;Medzhitov R
CD4+ T细胞的分化是由专门的抗原呈递细胞调节的。树突状细胞（DC）产生细胞因子，其促进初始CD4+ T细胞分化为T辅助1（Th1）、Th17和诱导性T调节（iTreg）细胞。然而，Th2细胞应答的启动仍然知之甚少，尽管可能涉及不止一种机制。在这里，我们已经定义了一个特定的DC亚群，在体内的蛋白酶过敏原，以及感染与巴西日本圆线虫的Th2细胞分化。我们已经证明，这一子集是由转录因子干扰素调节因子4（IRF4），这是他们的分化和Th2细胞诱导功能所需的控制。已知IRF4控制Treg细胞中的Th2细胞分化和Th2细胞相关的抑制功能。我们的发现表明IRF4也在DC中起作用，在DC中它控制Th2细胞应答的启动。
CD4+ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4+ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, although it is likely that more than one mechanism might be involved. Here we have defined a specific DC subset that is involved in Th2 cell differentiation in vivo in response to a protease allergen, as well as infection with Nippostrongylus brasiliensis. We have demonstrated that this subset is controlled by the transcription factor interferon regulatory factor 4 (IRF4), which is required for their differentiation and Th2 cell-inducing function. IRF4 is known to control Th2 cell differentiation and Th2 cell-associated suppressing function in Treg cells. Our finding suggests that IRF4 also plays a role in DCs where it controls the initiation of Th2 cell responses.
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影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
DOI：
10.1084/jem.20100734
发表时间：
2010-09-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Phythian-Adams AT;Cook PC;Lundie RJ;Jones LH;Smith KA;Barr TA;Hochweller K;Anderton SM;Hämmerling GJ;Maizels RM;MacDonald AS
通讯作者：
MacDonald AS
DOI：
10.1084/jem.20062648
发表时间：
2007-07-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Caton ML;Smith-Raska MR;Reizis B
通讯作者：
Reizis B
DOI：
10.4049/jimmunol.1102613
发表时间：
2012-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bajaña S;Roach K;Turner S;Paul J;Kovats S
通讯作者：
Kovats S
影响因子：
15.3
作者：
King, Irah L.;Kroenke, Mark A.;Segal, Benjamin M.
通讯作者：
Segal, Benjamin M.