Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure
Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure
复制标题
DOI：
10.1016/s0021-9150(98)00178-6
复制
发表时间：
1998-12-01
期刊：
影响因子：
5.3
通讯作者：
Chen, CJ
中科院分区：
文献类型：
--
作者：
Hsueh, YM;Wu, WL;Chen, CJ
为了阐明砷相关的缺血性心脏病(ISHD)与血清抗氧化剂微量营养素水平之间的关系，一项以社区为基础的健康调查招募了居住在台湾砷病高流行村30岁或以上的居民。采用结构化问卷调查，通过饮用自来水获得长期砷暴露史，并在招募时采集空腹血清样本。选择74例经心电图和Rose问卷调查确诊的ISHD患者和193例年龄、性别相匹配的健康对照组，采用高效液相色谱法测定血清微量营养素水平。在ISHD的风险和饮用高砷自流井水的持续时间之间存在显著的生物梯度。血清α-胡萝卜素和β-胡萝卜素水平与砷相关的ISHD有显著的反向剂量-反应关系，而血清视黄醇、番茄红素和α-生育酚水平则没有。多变量分析显示饮用自来水井水时间和低血清胡萝卜素水平对砷相关性ISHD有协同作用。与砷相关的ISHD风险的增加也与高血压和体重指数升高有关，但与血脂水平、吸烟和饮酒无关。这些发现似乎表明，与砷相关的ISHD具有至少部分不同于ISHD的致病机制，与长期接触砷无关。(C)1998爱思唯尔爱尔兰科学有限公司。保留所有权利。
To elucidate the association between arsenic-related ischemic heart disease (ISHD) and serum antioxidant micronutrient level, residents aged 30 or older living in arseniasis-hyperendemic villages in Taiwan were recruited in a community-based health survey. A structured questionnaire was used to obtain a history of long-term exposure to arsenic through consuming artesian well water and fasting serum samples were also collected at the recruitment. A. total of 74 patients affected with ISHD, who were diagnosed through both electrocardiography and Rose questionnaire interview, and 193 age-sex-matched healthy controls were selected for the examination of serum levels of micronutrients by high performance liquid chromatography (HPLC). There was a significant biological gradient between the risk of ISHD and the duration of consuming high-arsenic artesian well water. A significant reverse dose-response relationship with arsenic-related ISHD was observed for serum level of alpha- and beta-carotene, but not for serum levels of retinol, lycopene and alpha-tocopherol. Multivariate analysis showed a synergistic interaction on arsenic-related ISHD between duration of consuming artesian well water and low serum carotene level. An increased risk of arsenic-related ISHD was also associated with hypertension and elevated body mass index, but not with serum lipid profile, cigarette smoking and alcohol drinking. The findings seem to suggest that arsenic-related ISHD has a pathogenic mechanism which is at least partially different from that of ISHD unrelated to long-term exposure to arsenic. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.