Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice
Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice
复制标题
自身免疫调节因子缺乏会损害小鼠骨髓源性树突状细胞的免疫耐受作用
DOI：
10.1080/08916934.2017.1422124
复制
发表时间：
2018-01-01
期刊：
影响因子：
3.5
通讯作者：
Yang, Wei
中科院分区：
文献类型：
--
作者：
Huo, Feifei;Li, Dongbei;Yang, Wei
As a transcription factor, autoimmune regulator (Aire) participates in thymic negative selection and maintains immune tolerance mainly by regulating the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs). Aire is also expressed in dendritic cells (DCs). DCs are professional antigen-presenting cells (APCs) that affect the differentiation of T cells toward distinct subpopulations and participate in the immune response and tolerance, thereby playing an important role in maintaining homeostasis. To determine the role of Aire in maintaining immune tolerance by bone marrow-derived dendritic cells (BMDCs), in the present study we utilized Aire-knockout mice to examine the changes of maturation status and TRAs expression on BMDCs, additionally investigate the differentiation of CD4(+) T cells. The results showed that expression of costimulatory molecule and major histocompatibility complex class II (MHC-II) molecule was increased and expression of various TRAs was decreased in BMDCs from Aire-knockout mice. Aire deficiency reduced the differentiation of naive CD4(+) T cells into type 2T helper (Th2) cells and regulatory T cells (Tregs) but enhanced the differentiation of naive CD4(+) T cells into Th1 cells, Th17 cells, and follicular helper T (Tfh) cells. The results demonstrate that Aire expressed by BMDCs plays an important role in the maintenance of homeostasis by regulating TRA expression and the differentiation of T cell subsets.
