A surface energetic criterion of blood compatibility of foreign surfaces
A surface energetic criterion of blood compatibility of foreign surfaces
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DOI：
10.1016/0021-9797(84)90055-9
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发表时间：
1984-10
影响因子：
9.9
通讯作者：
E. Ruckenstein;S. V. Gourisankar
中科院分区：
文献类型：
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作者：
E. Ruckenstein;S. V. Gourisankar
基于最小化血液成分吸附的热力学驱动力以及保持机械稳定的血液-生物材料界面的双重考虑，建议了异物表面生物相容性的表面能量标准。前一个条件要求血液-生物材料界面张力γsl非常低（最好为零），后一个条件要求γsl值足够高。为了协调这两个要求，血液-生物材料界面张力为1至3达因/厘米的量级被认为是令人满意的。该数值范围的选择是基于这样的事实，即与血液高度相容并且其与血浆的界面也是机械稳定的血液细胞成分与血浆的界面张力通常保持在上述范围内。使用仅考虑非特异性相互作用的简化模型（即，色散和极性），表明当生物材料的极性和色散表面自由能分量分别足够接近血液的相应表面自由能对应物时，可以满足上述标准。由于这种情况，即使固体的总表面自由能略有不同，也能保持与血液同样相容。还应注意，由于这种情况，非极性表面预计不会与血液保持长期相容性。第二，许多固体表面的能力，在水的环境中进行结构改变（在空气环境中相比）进行了讨论，在血液环境中的生物材料的表面能量特性的影响。基于这种考虑和建议的表面能量标准，一些突出的生物材料的性能进行了检查。最后，讨论了提高高分子生物材料的表面能量特性（通过紫外线照射其表面），从而提高其血液相容性的可能性。
Based on the twin considerations of minimizing the thermodynamic driving force for the adsorption of blood components as well as maintaining a mechanically stable blood-biomaterial interface, a surface energetic criterion of biocompatibility of foreign surfaces is suggested. While the former requirement calls for a very low (preferably zero) blood-biomaterial interfacial tension, γsl, the latter condition demands a sufficiently high value of γsl. In order to reconcile these two requirements, a blood-biomaterial interfacial tension of the order of 1 to 3 dyn/cm is considered satisfactory. This range of values is selected on the basis of the fact that the cellular elements of blood, which are highly compatible with blood and whose interface with blood plasma is also mechanically stable, maintain an interfacial tension with blood plasma generally in the above mentioned range. Using a simplified model which accounts only for the nonspecific interactions (i.e., dispersion and polar) between blood and biomaterial, it is shown that the above criterion can be satisfied when the polar and dispersion surface free energy components of a biomaterial are separately sufficiently near to their respective surface-free energy counterparts of blood. As a result of this condition, even solids which differ appreciably in their total surface free energies can remain equally compatible with blood. It is also noted that, as a result of this condition, nonpolar surfaces are not expected to remain in long-term compatibility with blood. Second, the ability of many solid surfaces to undergo structural alterations in the aqueous environment (in comparison to the air environment) is discussed in relation to its implications for the surface energetic properties of biomaterials in the blood environment. Based on this consideration and the suggested surface energetic criterion, the performance of some prominent biomaterials is examined. Finally, the possibility of improving the surface energetic properties of polymeric biomaterials (by ultraviolet irradiation of their surfaces) and thereby enhancing their blood compatibilities, is discussed.