Occupational exposure to pesticides and risk of non-Hodgkin's lymphoma
Occupational exposure to pesticides and risk of non-Hodgkin's lymphoma
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DOI：
10.1093/aje/kwi292
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发表时间：
2005-11-01
影响因子：
5
通讯作者：
Armstrong, BK
中科院分区：
文献类型：
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作者：
Fritschi, L;Benke, G;Armstrong, BK
接触杀虫剂可能是非霍奇金淋巴瘤的危险因素，但尚不确定涉及哪种类型的杀虫剂。2000-2001年进行了一项以人群为基础的病例对照研究，采用了评估职业农药暴露的详细方法。澳大利亚两个州(n=694)和对照组(n=694)的非霍奇金淋巴瘤病例均选自澳大利亚选民名册。在对年龄、性别、种族和居住地进行调整后，使用Logistic回归估计与暴露于杀虫剂亚类相关的非霍奇金淋巴瘤的风险。大约10%的病例和对照曾接触过杀虫剂。大量接触任何杀虫剂都会使患非霍奇金淋巴瘤的风险增加两倍(优势比=3.09，95%可信区间：1.42，6.70)。大量接触有机氯、有机磷和“其他杀虫剂”(除除草剂以外的所有其他杀虫剂)和除草剂以外的除草剂的受试者也有类似的风险增加，尽管这种增加只对“其他杀虫剂”有统计学意义。没有任何暴露指标(概率、水平、频率、持续时间或暴露年限)与非霍奇金淋巴瘤有关。对世界卫生组织主要非霍奇金淋巴瘤亚型的分析表明，对滤泡性淋巴瘤有更强的疗效。大量职业性农药暴露增加了非霍奇金淋巴瘤的风险，这与之前的工作是一致的。
Pesticide exposure may be a risk factor for non-Hodgkin's lymphoma, but it is not certain which types of pesticides are involved. A population-based case-control study was undertaken in 2000-2001 using detailed methods of assessing occupational pesticide exposure. Cases with incident non-Hodgkin's lymphoma in two Australian states (n = 694) and controls (n = 694) were chosen from Australian electoral rolls. Logistic regression was used to estimate the risks of non-Hodgkin's lymphoma associated with exposure to subgroups of pesticides after adjustment for age, sex, ethnic origin, and residence. Approximately 10% of cases and controls had incurred pesticide exposure. Substantial exposure to any pesticide was associated with a trebling of the risk of non-Hodgkin's lymphoma (odds ratio = 3.09, 95% confidence interval: 1.42, 6.70). Subjects with substantial exposure to organochlorines, organophosphates, and "other pesticides" (all other pesticides excluding herbicides) and herbicides other than phenoxy herbicides had similarly increased risks, although the increase was statistically significant only for "other pesticides." None of the exposure metrics (probability, level, frequency, duration, or years of exposure) were associated with non-Hodgkin's lymphoma. Analyses of the major World Health Organization subtypes of non-Hodgkin's lymphoma suggested a stronger effect for follicular lymphoma. These increases in risk of non-Hodgkin's lymphoma with substantial occupational pesticide exposure are consistent with previous work.