Spatial confinement of chemically engineered cancer cells using large graphene oxide sheets: a new mode of cancer therapy.
Spatial confinement of chemically engineered cancer cells using large graphene oxide sheets: a new mode of cancer therapy.
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DOI：
10.1039/d1nh00350j
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发表时间：
2021-09
影响因子：
9.7
通讯作者：
Tianshu Chen;Qianqian Zhang;Yuchen Song;Albertina N Isak;Xiaochen Tang;Hao Wang;Zhongliang Ma;F. Sun;Qiuhui Pan;Xiaoli Zhu
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文献类型：
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作者：
Tianshu Chen;Qianqian Zhang;Yuchen Song;Albertina N Isak;Xiaochen Tang;Hao Wang;Zhongliang Ma;F. Sun;Qiuhui Pan;Xiaoli Zhu
高效治疗癌症，同时消除副作用一直是癌症研究的圣杯。然而，挑战来自癌细胞和正常细胞的分子特征的相似性，因为真正特异性的癌症生物标志物即使不是完全不可用，也是极其稀缺的。通常，作为治疗靶点的生物标志物存在于健康细胞和癌症上，但水平不同，不仅会引起脱靶副作用，还会引起靶向副作用。这项工作报告了一种新的癌症治疗概念，即细胞的空间限制以抑制细胞迁移和侵袭，这直接解决了细胞水平上癌症的定义特征，即不受限制的分裂。使用大尺寸氧化石墨烯（LS-GO），可以修补细胞表面。与常规化疗不同，这种空间限制不影响非分裂细胞的活力，但在体外和体内显著抑制肿瘤细胞的迁移和侵袭。这种新概念有可能成为许多癌症类型的通用治疗方法，减少副作用。
Treating cancer with high efficacy while eliminating side effects has been the holy grail of cancer research. The challenge, however, arises from the similarity in molecular traits of cancer cells and normal cells because truly specific cancer biomarkers are extremely scarce if not entirely unavailable. Often, biomarkers serving as the therapeutic targets are present on both healthy cells and cancers, but at different levels, causing not only off-target side effects but also on-target side effects. This work has reported a new concept of cancer treatment, spatial confinement of cells to inhibit cell migration and invasion, which directly addresses the defining trait of cancer on the cellular level, unchecked division. Using large sized graphene oxide (LS-GO), cell surfaces can be patched. Unlike conventional chemotherapy, this spatial confinement does not affect the viability of non-dividing cells but significantly inhibits tumor cell migration and invasion in vitro and in vivo. This new concept has the potential to become a general therapeutic for many cancer types with reduced side effects.