Biomechanical properties of the cornea measured by the Ocular Response Analyzer and their association with intraocular pressure and the central corneal curvature
Biomechanical properties of the cornea measured by the Ocular Response Analyzer and their association with intraocular pressure and the central corneal curvature
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DOI：
10.1111/j.1444-0938.2009.00414.x
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发表时间：
2009-11-01
影响因子：
1.9
通讯作者：
Lira, Madalena
中科院分区：
文献类型：
--
作者：
Franco, Sandra;Lira, Madalena
背景：本研究的目的是探讨角膜的生物力学特性及其与眼压（IOP）、中央角膜厚度（CCT）和中央角膜曲率半径（Rc）的关系。方法：83只眼睛分为两组。对 63 只正常眼睛和 20 只激光原位角膜磨镶术 (LASIK) 后眼睛的角膜生物力学特性进行了测量。通过眼反应分析仪（ORA）测量眼压、角膜滞后（CH）和角膜阻力因子（CRF）。使用角膜地形图仪 Medmont E-300 和 Tomey SP-100 Handy 超声波测厚仪测量 Rc 和 CCT。还研究了 ORA 测量的其他参数，例如 TimeIn 和 TimeOut。 结果：正常眼的平均角膜滞后为 10.8 mmHg，CRF 为 10.6 mmHg。与中心曲率没有显着相关性。除角膜补偿眼压 (IOPcc) 外，ORA 测量的所有参数均与 CCT 显着相关。 ORA 测量的两种 IOP 的平均 CH 和 CRF 值相同。对于 LASIK 术后眼睛，CH 和 CRF 低于正常未手术眼睛。 LASIK 术后眼睛的 TimeIn 和 TimeOut 值也较低，这表明可以通过 ORA 测量获得额外的数据。结论：本研究的结果表明，使用眼反应分析仪测量的参数与中央角膜曲率半径之间不存在相关性。研究发现，与 LASIK 术后眼睛相比，正常眼睛的角膜生物力学特性有所不同。
Background:The aim of this study was to investigate the biomechanical properties of the cornea and their association with intraocular pressure (IOP), central corneal thickness (CCT) and the central corneal radius of curvature (Rc).Methods:Eighty-three eyes were divided into two groups. The biomechanical properties of the cornea were measured in 63 normal eyes and in 20 post-laser in situ keratomileusis (LASIK) eyes. The IOP, corneal hysteresis (CH) and corneal resistance factor (CRF) were measured by the Ocular Response Analyzer (ORA). The Rc and CCT were measured using the corneal topographer Medmont E-300 and the Tomey SP-100 Handy ultrasonic pachymeter. Other parameters measured by the ORA, such as TimeIn and TimeOut, were also studied.Results:A mean corneal hysteresis of 10.8 mmHg and CRF of 10.6 mmHg were recorded for the normal eyes. There was no significant association with central curvature. All parameters measured by the ORA showed a significant correlation with the CCT, except for the corneal-compensated intraocular pressure (IOPcc). Both IOPs measured by the ORA had the same values for the mean CH and CRF. For the post-LASIK eyes, the CH and CRF were lower than in the normal non-operated eyes. The TimeIn and the TimeOut also presented lower values for the post-LASIK eyes, suggesting that additional data can be obtained with the ORA measurements.Conclusions:The results of this study indicate that there is no correlation between the parameters measured with the Ocular Response Analyzer and central corneal radius of curvature. Some of the biomechanical properties of the cornea studied were found to differ in the normal eyes compared to the post-LASIK eyes.