Cardiac Size and Function in Acromegaly
Cardiac Size and Function in Acromegaly
复制标题
肢端肥大症的心脏大小和功能
DOI：
10.1161/01.cir.56.5.863
复制
发表时间：
1977
期刊：
影响因子：
37.8
通讯作者：
J. Ehrhardt
中科院分区：
文献类型：
--
作者：
James B. Martins;R. Kerber;B. Sherman;M. Marcus;J. Ehrhardt
对16例肢端肥大症患者进行超声心动图、心音图、负荷心电图铊灌注扫描和放射性核素左室心血管造影。6例合并高血压或冠心病的患者出现左室回声质量指数增加、环周纤维缩短速度减慢或射血前期与左室射血时间比值升高。同心性左心室肥大还发现在3例患者中，除了肢端肥大症超过13年的持续时间或空腹生长激素浓度大于100 ng/ml之外，没有已知的病因。这三个人中的一个也有左心室功能障碍。在病程较短或生长激素浓度较低或治疗后生长激素浓度正常的其他肢端肥大症患者中，未发现肥大或心室功能障碍。冠状动脉和高血压性心脏病的高患病率与肢端肥大症有关。少数肢端肥大症患者具有特异性、潜在可逆性心肌病，可能与肢端肥大症延长或生长激素浓度过高有关。
Sixteen acromegalic patients underwent echocardiography, phonocardiography, stress electrocardiography with Thallium perfusion scanning and gated radioisotope left ventricular angiocardiograms. Abnormalities consisting of increased echo left ventricular mass index, low velocity of circumferential fiber shortening or elevated pre-ejection period to left ventricular ejection time ratio were found in six patients with coexistent hypertension or coronary disease. Concentric left ventricular hypertrophy was also found in three patients with no known etiology other than acromegaly of greater than thirteen years' duration or with fasting growth hormone concentrations greater than 100 ng/ml. One of these three also had left ventricular dysfunction. Neither hypertrophy nor ventricular dysfunction was found in other acromegalics with shorter duration of disease or lower growth hormone concentrations, or with normal growth hormone concentrations after therapy. A high prevalence of coronary artery and hypertensive heart disease is associated with acromegaly. A few patients with acromegaly have a specific, potentially reversible cardiomyopathy probably related to prolonged acromegaly or very high growth hormone concentrations.