alpha v Integrins as receptors for tumor targeting by circulating ligands
alpha v Integrins as receptors for tumor targeting by circulating ligands
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DOI：
10.1038/nbt0697-542
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发表时间：
1997-06-01
影响因子：
46.9
通讯作者：
Ruoslahti, E
中科院分区：
文献类型：
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作者：
Pasqualini, R;Koivunen, E;Ruoslahti, E
展示一种含有Arg-Gly-Asp(RGD)的多肽，当静脉注射到荷瘤小鼠体内时，该噬菌体对定位于肿瘤的av整合素具有高亲和力。从恶性黑色素瘤和乳腺癌中回收的av导向的RGD噬菌体数量比对照噬菌体高得多。抗体在肿瘤血管中检测到av导向的RGD噬菌体，但在几个正常组织中检测不到。这些结果表明，肿瘤血管中存在的αv整合素可以与循环配体结合，针对这些整合素的RGD多肽可能是肿瘤靶向诊断和治疗的合适工具。
Phage displaying an Arg-Gly-Asp (RGD)-containing peptide with a high affinity for av integrins homed to tumors when injected intravenously into tumor-bearing mice. A substantially higher amount of av-directed RGD phage than control phage was recovered from malignant melanomas and breast carcinoma. Antibodies detected the av-directed RGD phage in tumor blood vessels, but not in several normal tissues. These results show that the alpha v integrins present in tumor blood vessels can bind circulating ligands and that RGD peptides selective for these integrins may be suitable tools in tumor targeting for diagnostic and therapeutic purposes.