Exogenous H2S enhances mice gastric smooth muscle tension through S‐sulfhydration of KV4.3, mediating the inhibition of the voltage‐dependent potassium current

Exogenous H2S enhances mice gastric smooth muscle tension through S‐sulfhydration of KV4.3, mediating the inhibition of the voltage‐dependent potassium current
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DOI：
10.1111/nmo.12451
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发表时间：
2014-12
期刊：
Neurogastroenterology & Motility
影响因子：
3.5
通讯作者：
D. Liu;X. Huang;Xiang-Min Meng;C.-M. Zhang;H-L Lu;Y.-C. Kim;W. Xu
D. Liu;X. Huang;Xiang-Min Meng;C.-M. Zhang;H-L Lu;Y.-C. Kim;W. Xu
中科院分区：
医学3区
文献类型：
--
作者：
D. Liu;X. Huang;Xiang-Min Meng;C.-M. Zhang;H-L Lu;Y.-C. Kim;W. Xu

文献摘要

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硫化氢(H_2S)对胃运动有兴奋作用，但其潜在的分子机制尚不清楚。在这项研究中，我们旨在研究硫化氢的可能靶点，并确定在硫化氢诱导的收缩过程中，硫化氢如何影响其靶蛋白。
Hydrogen sulfide (H2S) has been shown to have an excitatory effect on gastric motility, but the underlying molecular mechanism is unclear. In this study, we aimed to investigate the possible targets of H2S and determine how H2S affects its target proteins during H2S‐induced contraction.